P46198 · IF2M_BOVIN

  • Protein
    Translation initiation factor IF-2, mitochondrial
  • Gene
    MTIF2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

Features

Showing features for binding site.

1727100200300400500600700
TypeIDPosition(s)Description
Binding site187-194GTP (UniProtKB | ChEBI)
Binding site234-237GTP (UniProtKB | ChEBI)
Binding site288-291GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosomal small subunit binding
Molecular Functiontranslation factor activity, RNA binding
Molecular Functiontranslation initiation factor activity
Biological Processmitochondrial translational initiation
Biological Processribosome disassembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Translation initiation factor IF-2, mitochondrial
  • Short names
    IF-2(Mt); IF-2Mt; IF2(mt)

Gene names

    • Name
      MTIF2

Organism names

  • Taxonomic identifier
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    P46198
  • Secondary accessions
    • A6QR53

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-29Mitochondrion
ChainPRO_000001447930-727Translation initiation factor IF-2, mitochondrial
Modified residue688Phosphothreonine

Keywords

Proteomic databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain178-348tr-type G
Region187-194G1
Region212-216G2
Region234-237G3
Region288-291G4
Region324-326G5

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    727
  • Mass (Da)
    81,764
  • Last updated
    1995-11-01 v1
  • Checksum
    FD703F91D9AB1F28
MNRKILKLENLLRFHTICRQLHSLCQRRMLAQWRHMFSSAYAVHTAQLYTRPWQTDALLRAALSQRRLLVTKKEKRSQKSPLPSTKSKKEVEVWLGMTVEELARAMEKDIDCVYESLMNTAIDIDSLETHSRLDEVWIKEVIKKSGMKLKWSKLKQDKVRENKDAVKRPQADPALLIPRSPVVTIMGHVDHGKTTLLDKLRKTQVAAMEAGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVESIQHAKDAHVPIVLAINKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVHVSALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFTDKGRGPVTTAIIQRGTLRKGSILVAGKSWAKVRLMFDENGRAVNEAYPSMPVGIIGWRDLPSAGDEILEVESEPRAREVVDWRKYEQEQEKNKEDLKLIEEKRKEHQEAHRKDREKYGTVHWKERSYIKYREKRQQQPLKPKEKLERDSNVLPVIVKGDVDGSVEAILNVMDTYDASHECELDLVHFGVGDISENDVNLAETFHGVIYGFNVNAGNVIQQLAAKKGVKIKLHKIIYRLIEDLQEELSSRLPCIVEEHPIGEASILATFSITEGKKKVPVAGCRVQKGQIEKQKKFKLIRNGHVIWKGSLISLKHHKDDTSVVKTGMDCGLSLDEEKIEFKVGDAIICYEEKEVPAKTSWDPGF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L37835
EMBL· GenBank· DDBJ
AAB05558.1
EMBL· GenBank· DDBJ
mRNA
BC150118
EMBL· GenBank· DDBJ
AAI50119.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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