P46156 · GLL1_CHICK

Function

function

Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentsecretory granule
Molecular FunctionCCR6 chemokine receptor binding
Molecular Functionchemoattractant activity
Biological Processcell chemotaxis
Biological Processdefense response
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processkilling of cells of another organism

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Gallinacin-1
  • Short names
    Gal-1
  • Alternative names
    • Beta-defensin 1

Gene names

    • Name
      GAL1

Organism names

  • Taxonomic identifier
  • Strains
    • Guangxi Huang
    • Huiyang bearded
    • Qingyuan Ma
    • Taihe silkies
    • Xinghua
    • Broiler
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    P46156
  • Secondary accessions
    • Q09MK1
    • Q0PWH4
    • Q6B9W7
    • Q6GXJ4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, propeptide, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
PropeptidePRO_000000700820-25
PeptidePRO_000000700926-65Gallinacin-1
Disulfide bond31↔59
Disulfide bond38↔53
Disulfide bond43↔60

Keywords

Proteomic databases

Expression

Tissue specificity

Strong expression in the bone marrow, lung, testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain and pancreas. Expressed in the vagina, ovarian stroma and the theca and granulosa layers of the ovarian follicle.

Induction

Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Repressed in the granulosa layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis. Expression in the kidney and liver is not affected by intravenous injection of LPS.

Developmental stage

Detected in the theca layer of the ovarian follicle in the white follicle (WF) stage, but decreases throughout the F1, F3, F5, and postovulatory follicle stages. Detected in the granulosa layer of the ovarian follicle in the white follicle (WF) stage, F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the beta-defensin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    65
  • Mass (Da)
    7,209
  • Last updated
    1998-12-15 v2
  • Checksum
    17665B795A22521F
MRIVYLLLPFILLLAQGAAGSSQALGRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIWG

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict5in Ref. 5; ABI49682
Sequence conflict8in Ref. 3; AAT76974

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF033335
EMBL· GenBank· DDBJ
AAC36051.1
EMBL· GenBank· DDBJ
mRNA
AY621316
EMBL· GenBank· DDBJ
AAT48925.1
EMBL· GenBank· DDBJ
Genomic DNA
AY672653
EMBL· GenBank· DDBJ
AAT76974.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ677632
EMBL· GenBank· DDBJ
ABG73366.1
EMBL· GenBank· DDBJ
mRNA
DQ858338
EMBL· GenBank· DDBJ
ABI48254.1
EMBL· GenBank· DDBJ
mRNA
DQ858324
EMBL· GenBank· DDBJ
ABI48240.1
EMBL· GenBank· DDBJ
mRNA
DQ858311
EMBL· GenBank· DDBJ
ABI48227.1
EMBL· GenBank· DDBJ
mRNA
DQ858298
EMBL· GenBank· DDBJ
ABI48214.1
EMBL· GenBank· DDBJ
mRNA
DQ862462
EMBL· GenBank· DDBJ
ABI49682.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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