P46156 · GLL1_CHICK
- ProteinGallinacin-1
- GeneGAL1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | secretory granule | |
Molecular Function | CCR6 chemokine receptor binding | |
Molecular Function | chemoattractant activity | |
Biological Process | cell chemotaxis | |
Biological Process | defense response | |
Biological Process | defense response to bacterium | |
Biological Process | defense response to fungus | |
Biological Process | killing of cells of another organism |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGallinacin-1
- Short namesGal-1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionP46156
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, peptide, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MRIVYLLLPFILLLAQGAA | ||||||
Propeptide | PRO_0000007008 | 20-25 | ||||
Sequence: GSSQAL | ||||||
Peptide | PRO_0000007009 | 26-65 | Gallinacin-1 | |||
Sequence: GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIWG | ||||||
Disulfide bond | 31↔59 | |||||
Sequence: CFRKSGFCAFLKCPSLTLISGKCSRFYLC | ||||||
Disulfide bond | 38↔53 | |||||
Sequence: CAFLKCPSLTLISGKC | ||||||
Disulfide bond | 43↔60 | |||||
Sequence: CPSLTLISGKCSRFYLCC |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Strong expression in the bone marrow, lung, testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain and pancreas. Expressed in the vagina, ovarian stroma and the theca and granulosa layers of the ovarian follicle.
Induction
Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Repressed in the granulosa layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis. Expression in the kidney and liver is not affected by intravenous injection of LPS.
Developmental stage
Detected in the theca layer of the ovarian follicle in the white follicle (WF) stage, but decreases throughout the F1, F3, F5, and postovulatory follicle stages. Detected in the granulosa layer of the ovarian follicle in the white follicle (WF) stage, F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length65
- Mass (Da)7,209
- Last updated1998-12-15 v2
- Checksum17665B795A22521F
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 5 | in Ref. 5; ABI49682 | ||||
Sequence: Y → C | ||||||
Sequence conflict | 8 | in Ref. 3; AAT76974 | ||||
Sequence: L → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF033335 EMBL· GenBank· DDBJ | AAC36051.1 EMBL· GenBank· DDBJ | mRNA | ||
AY621316 EMBL· GenBank· DDBJ | AAT48925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY672653 EMBL· GenBank· DDBJ | AAT76974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ677632 EMBL· GenBank· DDBJ | ABG73366.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ858338 EMBL· GenBank· DDBJ | ABI48254.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ858324 EMBL· GenBank· DDBJ | ABI48240.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ858311 EMBL· GenBank· DDBJ | ABI48227.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ858298 EMBL· GenBank· DDBJ | ABI48214.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ862462 EMBL· GenBank· DDBJ | ABI49682.1 EMBL· GenBank· DDBJ | mRNA |