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P46103 · DRTS_PLAVN

  • Protein
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site25-31NADP+ (UniProtKB | ChEBI)
Binding site40substrate
Binding site93-95NADP+ (UniProtKB | ChEBI)
Binding site114-117NADP+ (UniProtKB | ChEBI)
Binding site154substrate
Binding site155-162NADP+ (UniProtKB | ChEBI)
Binding site160substrate
Binding site175substrate

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functiondihydrofolate reductase activity
Molecular FunctionNADP binding
Molecular Functionthymidylate synthase activity
Biological Processdihydrofolate metabolic process
Biological Processfolic acid metabolic process
Biological Processmethylation
Biological Processnucleotide biosynthetic process
Biological Processone-carbon metabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • Short names
    DHFR-TS

Including 2 domains:

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Vinckeia)

Accessions

  • Primary accession
    P46103

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001863501-182Bifunctional dihydrofolate reductase-thymidylate synthase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-182DHFR

Sequence similarities

In the N-terminal section; belongs to the dihydrofolate reductase family.
In the C-terminal section; belongs to the thymidylate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    182
  • Mass (Da)
    20,925
  • Last updated
    1995-11-01 v1
  • MD5 Checksum
    BAFCE8C3F55819890DF2EACB2A45C650
AICACCKVLNSNEKASCFSNKTFKGLGNAGGLPWKCNSVDMKHFVSVTSYVNENNYIRLKWKRDKYIKENNVKVNTDGIPSIDKLQNIVVMGKTSWESIPSKFKPLENRINIILSRTLKKENLAKEYSNVIIIKSVDELFPILKCIKYYKCFIIGGASVYKEFLDRNLIKKIYFTRINNAYT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue182

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L28121
EMBL· GenBank· DDBJ
AAA29582.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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