P45996 · OMP53_HAEIF

  • Protein
    Outer membrane protein P5
  • Gene
    ompA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a fimbriae subunit, allowing adhesion to host cells.
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.

Miscellaneous

Non-typeable Haemophilus influenzae (NTHi) is a primary pathogen in otitis media (inflammation of the middle ear).

Biotechnology

Immunization of chinchillas with this protein provides partial protection against subsequent infection, suggesting it might be a useful vaccine candidate.

Features

Showing features for site.

135950100150200250300350
TypeIDPosition(s)Description
Site86Part of salt bridge gating mechanism
Site181Part of salt bridge gating mechanism

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell outer membrane
Cellular Componentpilus
Cellular Componentpore complex
Molecular Functionporin activity
Biological Processcell adhesion
Biological Processmonoatomic ion transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Outer membrane protein P5
  • Short names
    OMP P5
  • Alternative names
    • Fimbrin
    • Outer membrane porin A
    • Outer membrane protein A

Gene names

    • Name
      ompA
    • Synonyms
      ompP5

Organism names

  • Taxonomic identifier
  • Strain
    • NTHi 1128
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus

Accessions

  • Primary accession
    P45996

Subcellular Location

Cell outer membrane
; Multi-pass membrane protein
Fimbrium
Note: Antisera against this protein label the whole length of fimbriae.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-37Beta stranded
Transmembrane64-75Beta stranded
Transmembrane83-91Beta stranded
Transmembrane110-121Beta stranded
Transmembrane126-134Beta stranded
Transmembrane164-173Beta stranded
Transmembrane178-185Beta stranded
Transmembrane211-219Beta stranded

Keywords

Phenotypes & Variants

Disruption phenotype

No fimbrae seen on bacteria, the outer membrane blebs significantly, bacterial adhesion to human oropharyngeal cells decreases about 65%, significantly reduced ear infections in chinchilla.

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000002010922-359Outer membrane protein P5
Disulfide bond332↔344

Keywords

Interaction

Subunit

Monomer and homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain233-359OmpA-like

Domain

The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    359
  • Mass (Da)
    38,340
  • Last updated
    1995-11-01 v1
  • Checksum
    576B1C59B4818C37
MKKTAIALVVAGLAAASVAQAAPQENTFYAGVKAGQGSFHDGINNNGAIKKGLSSSNYGYRRNTFTYGVFGGYQILNQDNFGLAAELGYDDFGRAKLREAGKPKAKHTNHGAYLSLKGSYEVLDGLDVYGKAGVALVRSDYKFYEDANGTRDHKKGRHTARASGLFAVGAEYAVLPELAVRLEYQWLTRVGKYRPQDKPNTAINYNPWIGCINAGISYRFGQGEAPVVAAPEMVSKTFSLNSDVTFAFGKANLKPQAQATLDSVYGEISQVKSRKVAVAGYTNRIGSDAFNVKLSQERADSVANYFVAKGVAADAISATGYGEANPVTGATCDQVKGRKALIACLAPDRRVEIAVNGTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L08448
EMBL· GenBank· DDBJ
AAA24959.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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