P45985 · MP2K4_HUMAN
- ProteinDual specificity mitogen-activated protein kinase kinase 4
- GeneMAP2K4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids399 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Activity regulation
Features
Showing features for site, binding site, active site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity mitogen-activated protein kinase kinase 4
- EC number
- Short namesMAP kinase kinase 4; MAPKK 4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP45985
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_062963 | 16 | in dbSNP:rs17855590 | |||
Sequence: S → R | ||||||
Natural variant | VAR_040818 | 142 | in a lung squamous cell carcinoma sample; somatic mutation | |||
Sequence: Q → L | ||||||
Natural variant | VAR_040819 | 154 | in a colorectal adenocarcinoma sample; somatic mutation; dbSNP:rs1567657403 | |||
Sequence: R → W | ||||||
Natural variant | VAR_040820 | 234 | in an ovarian serous carcinoma sample; somatic mutation | |||
Sequence: N → I | ||||||
Natural variant | VAR_040821 | 251 | in a metastatic melanoma sample; somatic mutation | |||
Sequence: S → N | ||||||
Natural variant | VAR_040822 | 279 | in a colorectal adenocarcinoma sample; somatic mutation; dbSNP:rs753665559 | |||
Sequence: A → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 869 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylalanine | ||||
Sequence: A | |||||||
Chain | PRO_0000086381 | 2-399 | UniProt | Dual specificity mitogen-activated protein kinase kinase 4 | |||
Sequence: AAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD | |||||||
Modified residue (large scale data) | 5 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 26 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 58 | UniProt | Asymmetric dimethylarginine; alternate | ||||
Sequence: R | |||||||
Modified residue | 58 | UniProt | Omega-N-methylarginine; alternate | ||||
Sequence: R | |||||||
Modified residue (large scale data) | 80 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 83 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 90 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 90 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 251 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 257 | UniProt | Phosphoserine; by MAP3K | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 257 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 261 | UniProt | Phosphothreonine; by MAP3K | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 394 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2, MAPK10/JNK3, MAPK11 and MAPK14. Interacts (via its DVD domain) with MAP3Ks activators like MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with ARRB1, ARRB2 and MAPK8IP3/JIP3
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P45985 | MAP3K1 Q13233 | 3 | EBI-447868, EBI-49776 | |
BINARY | P45985 | MAPK8 P45983 | 3 | EBI-447868, EBI-286483 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-40 | Disordered | ||||
Sequence: MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGK | ||||||
Region | 37-52 | D domain | ||||
Sequence: MQGKRKALKLNFANPP | ||||||
Domain | 102-367 | Protein kinase | ||||
Sequence: LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI | ||||||
Region | 364-387 | DVD domain | ||||
Sequence: HPFILMYEERAVEVACYVCKILDQ |
Domain
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P45985-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length399
- Mass (Da)44,288
- Last updated1995-11-01 v1
- ChecksumA472537F2F26770B
P45985-2
- Name2
- Differences from canonical
- 39-39: G → GFQINFCEKAQS
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_038838 | 39 | in isoform 2 | |||
Sequence: G → GFQINFCEKAQS | ||||||
Sequence conflict | 118 | in Ref. 4; CAG38801 | ||||
Sequence: K → R | ||||||
Sequence conflict | 179 | in Ref. 6; BAG35884 | ||||
Sequence: E → G | ||||||
Sequence conflict | 356 | in Ref. 10; AAH60764 | ||||
Sequence: P → L |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L36870 EMBL· GenBank· DDBJ | AAC41719.1 EMBL· GenBank· DDBJ | mRNA | ||
U17743 EMBL· GenBank· DDBJ | AAC50127.1 EMBL· GenBank· DDBJ | mRNA | ||
AF070090 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070080 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070081 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070082 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070083 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070084 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070085 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070086 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070087 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070088 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF070089 EMBL· GenBank· DDBJ | AAC24130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR536564 EMBL· GenBank· DDBJ | CAG38801.1 EMBL· GenBank· DDBJ | mRNA | ||
BT019676 EMBL· GenBank· DDBJ | AAV38482.1 EMBL· GenBank· DDBJ | mRNA | ||
AK131544 EMBL· GenBank· DDBJ | BAG54774.1 EMBL· GenBank· DDBJ | mRNA | ||
AK313053 EMBL· GenBank· DDBJ | BAG35884.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ015703 EMBL· GenBank· DDBJ | AAY22176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC005244 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005410 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471108 EMBL· GenBank· DDBJ | EAW89975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471108 EMBL· GenBank· DDBJ | EAW89974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471108 EMBL· GenBank· DDBJ | EAW89976.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC036032 EMBL· GenBank· DDBJ | AAH36032.1 EMBL· GenBank· DDBJ | mRNA | ||
BC060764 EMBL· GenBank· DDBJ | AAH60764.1 EMBL· GenBank· DDBJ | mRNA |