P45972 · ZTF17_CAEEL
- ProteinZinc finger transcription factor family protein 17
- Geneztf-17
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids705 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Probable transcription factor (PubMed:24885717).
Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717).
Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | PcG protein complex | |
Cellular Component | transcription regulator complex | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc finger transcription factor family protein 17
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionP45972
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown reduces expression of homeobox protein lin-39 in vulval precursor cells at the larval L3 stage.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000065457 | 1-705 | Zinc finger transcription factor family protein 17 | |||
Sequence: MLRYQASVYGDSYGNDYHLPVQGPSTIASSNGLRSQQSKIIKRPPTNYKSIPACRLAPRRRLFVADGNGVQKSMTSSSGVTFPPPDYMKKMKENYESGKIIYIRRNNPGMKGNQMTGRLTTINSSIRAPSYHATSMSAGSVTLDTSGSAPKYVYRLPKAEYGNKFDENRPASNMYVPAQEPPKQHFTTVPACMSMGGEVVFEEELDDEIADLGADELTGDGFNADKSPKSESPDPYLKSSGPLVQPCMTSKSPSYNLLQRNRLQTSRFACPQQDCFWRGTNEMSMKKHMLVHGPKQPVIYDKTGEAMKVQLVQPKPKGVKCSECDTFAYSRPLLLRHMYDSHGIEAPLVKRTFANREMLQSWLDSLRETHAVEFVVSSGSKKWGRGLQVHYLTCSRSGDQKERPNKKYVRPPRPSIKCGRNCMAYLKIKQNPTVSELQIEGCLHHSGHEIDHTRMVLESNELASIGAIVDAVNEGVDVLGNVETIRSYLGSSGRFRLVTENGLIEQMPIWFEQYHRDMAAFNGTGYRNNSGPIPITNPYLSMTMKPSINGNRRLPYSGMTIKKELESITMKKAVPIRFNGGQLQNLEMNSSIEEYDESKVKIEMDDEDALATQSILKDDFEEFKTEDLFGLGGGDDEILCGGEEASGVTSNIDGILAANLPDNFNDPLCGMDLATDFSGPFDDDVFDELLGLTNFNDRHNNLNIS |
Proteomic databases
Expression
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P45972 | eps-8 G5ED33 | 3 | EBI-319208, EBI-2315916 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 215-239 | Disordered | ||||
Sequence: DELTGDGFNADKSPKSESPDPYLKS | ||||||
Zinc finger | 268-292 | C2H2-type 1 | ||||
Sequence: FACPQQDCFWRGTNEMSMKKHMLVH | ||||||
Zinc finger | 319-342 | C2H2-type 2 | ||||
Sequence: VKCSECDTFAYSRPLLLRHMYDSH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length705
- Mass (Da)78,529
- Last updated2011-07-27 v3
- Checksum7684C556F2388B7D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z36753 EMBL· GenBank· DDBJ | CAA85341.2 EMBL· GenBank· DDBJ | Genomic DNA |