P44123 · QUED_HAEIN
- Protein6-carboxy-5,6,7,8-tetrahydropterin synthase
- GenequeD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids141 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
Miscellaneous
The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).
Catalytic activity
- 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H+ + triphosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 23 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 27 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 29 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 71 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 131 | Charge relay system | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 6-carboxy-5,6,7,8-tetrahydropterin synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | queuosine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-carboxy-5,6,7,8-tetrahydropterin synthase
- EC number
- Short namesCPH4 synthase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionP44123
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000057925 | 1-141 | 6-carboxy-5,6,7,8-tetrahydropterin synthase | |||
Sequence: MFKISKEFSFDMAHLLDGHDGKCQNLHGHTYKLQVEISGDLYKSGAKKAMVIDFSDLKSIVKKVILDPMDHAFIYDQTNERESQIATLLQKLNSKTFGVPFRTTAEEIARFIFNRLKHDEQLSISSIRLWETPTSFCEYQE |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length141
- Mass (Da)16,322
- Last updated1995-11-01 v1
- Checksum6843517DEA5A7C3E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L42023 EMBL· GenBank· DDBJ | AAC22843.1 EMBL· GenBank· DDBJ | Genomic DNA |