P44123 · QUED_HAEIN

Function

function

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14Zn2+ (UniProtKB | ChEBI)
Active site23Proton acceptor
Binding site27Zn2+ (UniProtKB | ChEBI)
Binding site29Zn2+ (UniProtKB | ChEBI)
Active site71Charge relay system
Active site131Charge relay system

GO annotations

AspectTerm
Molecular Function6-carboxy-5,6,7,8-tetrahydropterin synthase activity
Molecular Functionmetal ion binding
Biological Processqueuosine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-carboxy-5,6,7,8-tetrahydropterin synthase
  • EC number
  • Short names
    CPH4 synthase
  • Alternative names
    • Queuosine biosynthesis protein QueD

Gene names

    • Name
      queD
    • Ordered locus names
      HI_1190

Organism names

Accessions

  • Primary accession
    P44123

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000579251-1416-carboxy-5,6,7,8-tetrahydropterin synthase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PTPS family. QueD subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    141
  • Mass (Da)
    16,322
  • Last updated
    1995-11-01 v1
  • Checksum
    6843517DEA5A7C3E
MFKISKEFSFDMAHLLDGHDGKCQNLHGHTYKLQVEISGDLYKSGAKKAMVIDFSDLKSIVKKVILDPMDHAFIYDQTNERESQIATLLQKLNSKTFGVPFRTTAEEIARFIFNRLKHDEQLSISSIRLWETPTSFCEYQE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L42023
EMBL· GenBank· DDBJ
AAC22843.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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