P43638 · MHP1_YEAST
- ProteinMAP-homologous protein 1
- GeneMHP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1398 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Essential for the formation and/or stabilization of microtubules. Binds to microtubules in vitro.
Miscellaneous
Present with 279 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | microtubule | |
Cellular Component | spindle | |
Molecular Function | structural constituent of cytoskeleton | |
Biological Process | fungal-type cell wall organization | |
Biological Process | negative regulation of microtubule depolymerization |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMAP-homologous protein 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP43638
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Cytoplasmic microtubules and mitotic spindles.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain, cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | |||
Chain | PRO_0000072754 | 1-1398 | MAP-homologous protein 1 | ||
Modified residue | 81 | Phosphoserine | |||
Cross-link | 221 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Modified residue | 222 | Phosphothreonine | |||
Modified residue | 309 | Phosphoserine | |||
Modified residue | 311 | Phosphoserine | |||
Modified residue | 354 | Phosphoserine | |||
Modified residue | 357 | Phosphoserine | |||
Modified residue | 577 | Phosphothreonine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P43638 | GLC7 P32598 | 6 | EBI-10880, EBI-13715 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 21-77 | Disordered | |||
Compositional bias | 26-48 | Polar residues | |||
Compositional bias | 60-77 | Polar residues | |||
Compositional bias | 90-106 | Polar residues | |||
Region | 90-144 | Disordered | |||
Region | 156-186 | Disordered | |||
Region | 191-210 | Disordered | |||
Region | 244-270 | Disordered | |||
Region | 296-382 | Disordered | |||
Compositional bias | 320-336 | Basic and acidic residues | |||
Compositional bias | 357-382 | Polar residues | |||
Region | 395-428 | Disordered | |||
Region | 515-548 | Disordered | |||
Compositional bias | 517-548 | Basic and acidic residues | |||
Compositional bias | 605-622 | Polar residues | |||
Region | 605-630 | Disordered | |||
Region | 1148-1169 | Disordered | |||
Region | 1203-1223 | Disordered | |||
Region | 1227-1258 | Tau/MAP repeat-like | |||
Region | 1313-1372 | Disordered | |||
Compositional bias | 1322-1357 | Polar residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,398
- Mass (Da)155,207
- Last updated1995-11-01 v1
- ChecksumE7925D75D80E0E58
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 26-48 | Polar residues | |||
Compositional bias | 60-77 | Polar residues | |||
Compositional bias | 90-106 | Polar residues | |||
Sequence conflict | 108 | in Ref. 1; CAA59145 | |||
Sequence conflict | 112-184 | in Ref. 1; CAA59145 | |||
Compositional bias | 320-336 | Basic and acidic residues | |||
Sequence conflict | 331 | in Ref. 1; CAA59145 | |||
Compositional bias | 357-382 | Polar residues | |||
Sequence conflict | 419 | in Ref. 1; CAA59145 | |||
Compositional bias | 517-548 | Basic and acidic residues | |||
Sequence conflict | 594-595 | in Ref. 1; CAA59145 | |||
Compositional bias | 605-622 | Polar residues | |||
Sequence conflict | 619 | in Ref. 1; CAA59145 | |||
Sequence conflict | 659-660 | in Ref. 1; CAA59145 | |||
Sequence conflict | 1175-1176 | in Ref. 1; CAA59145 | |||
Sequence conflict | 1309-1320 | in Ref. 1; CAA59145 | |||
Compositional bias | 1322-1357 | Polar residues | |||
Sequence conflict | 1339 | in Ref. 1; CAA59145 | |||
Sequence conflict | 1356 | in Ref. 1; CAA59145 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X84652 EMBL· GenBank· DDBJ | CAA59145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49317 EMBL· GenBank· DDBJ | CAA89333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08758.1 EMBL· GenBank· DDBJ | Genomic DNA |