P43619 · NADC_YEAST
- ProteinNicotinate-nucleotide pyrophosphorylase [carboxylating]
- GeneBNA6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids295 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in the catabolism of quinolinic acid (QA).
Miscellaneous
Present with 2660 molecules/cell in log phase SD medium.
Catalytic activity
- CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 107 | substrate | ||||
Sequence: R | ||||||
Binding site | 142-144 | substrate | ||||
Sequence: TRK | ||||||
Binding site | 166 | substrate | ||||
Sequence: R | ||||||
Binding site | 176 | substrate | ||||
Sequence: K | ||||||
Binding site | 206 | substrate | ||||
Sequence: E | ||||||
Binding site | 227 | substrate | ||||
Sequence: D | ||||||
Binding site | 256-258 | substrate | ||||
Sequence: SGG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
Biological Process | 'de novo' NAD biosynthetic process from tryptophan | |
Biological Process | NAD biosynthetic process | |
Biological Process | quinolinate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNicotinate-nucleotide pyrophosphorylase [carboxylating]
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP43619
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000155956 | 1-295 | Nicotinate-nucleotide pyrophosphorylase [carboxylating] | |||
Sequence: MPVYEHLLPVNGAWRQDVTNWLSEDVPSFDFGGYVVGSDLKEANLYCKQDGMLCGVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKNILLAERTALNILSRSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAVKIEVECLSEDEATEAIEAGADVIMLDNFKGDGLKMCAQSLKNKWNGKKHFLLECSGGLNLDNLEEYLCDDIDIYSTSSIHQGTPVIDFSLKLAH |
Proteomic databases
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length295
- Mass (Da)32,365
- Last updated1995-11-01 v1
- Checksum0680BB5DDC095050
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D50617 EMBL· GenBank· DDBJ | BAA09286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006940 EMBL· GenBank· DDBJ | DAA12490.1 EMBL· GenBank· DDBJ | Genomic DNA |