P43612 · SA155_YEAST

Function

function

Positive regulator of protein phosphatase SIT4. Involved in directing expression of TOR-repressed genes and in dephosphorylation of NPR1 in response to nutrient starvation. Negatively modulates K+ efflux of the cell by the Na+-K+/H+ antiporter NHA1.

Miscellaneous

Present with 5960 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentprotein serine/threonine phosphatase complex
Cellular ComponentU2-type spliceosomal complex
Molecular Functionprotein phosphatase binding
Molecular Functionprotein phosphatase regulator activity
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processnegative regulation of potassium ion export across plasma membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SIT4-associating protein SAP155

Gene names

    • Name
      SAP155
    • Ordered locus names
      YFR040W

Organism names

Accessions

  • Primary accession
    P43612
  • Secondary accessions
    • D6VTS3
    • Q96VG4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000975611-1002SIT4-associating protein SAP155
Modified residue58Phosphoserine
Modified residue255Phosphoserine
Modified residue613Phosphothreonine
Modified residue618Phosphothreonine

Post-translational modification

Hyperphosphorylated in the absence of SIT4.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Associates with the SIT4 protein phosphatase catalytic subunit in a cell-cycle-dependent manner.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P43612SIT4 P2060410EBI-16370, EBI-13707
BINARY P43612TIP41 Q121993EBI-16370, EBI-38123
View interactors in UniProtKB
View CPX-1864 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region51-131Disordered
Compositional bias60-99Basic and acidic residues
Compositional bias100-114Polar residues
Region214-273Disordered
Compositional bias223-238Acidic residues
Compositional bias239-255Basic and acidic residues
Compositional bias609-636Basic and acidic residues
Region609-645Disordered
Region868-901Disordered
Region940-1002Disordered
Compositional bias952-979Polar residues
Compositional bias980-1002Basic and acidic residues

Sequence similarities

Belongs to the SAPS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,002
  • Mass (Da)
    115,002
  • Last updated
    2011-09-21 v4
  • Checksum
    50CDC17130333022
MSFWPFGQNLNHSNINKILDEYFHVLHELERINPSVGKAIPAIFNNVQERGTSDSLDSIPEEYSHGDEVKTARGDQKSRFEKDDQQERYEKEEEERSMNSSESSTTSFSSGSTSKTDLDEEDISNATAPMMVTTKNLDNSFIERMLVETELLNELSRQNKTLLDFICFGFFFDKKTNKKVNNMEYLVDQLMECISKIKTATTVDLNNLIDYQEQQQLDDSSQEDVYVESDTEQEEEKEDDNNSNNKKRRKRGSSSFGNDDINNNDDDDDANEDDESAYLTKATIISEIFSLDIWLISESLVKNQSYLNKIWSIINQPNFNSENSPLVPIFLKINQNLLLTRQDQYLNFIRTERSFVDDMLKHVDISLLMDFFLKIISTDKIESPTGIIELVYDQNLISKCLSFLNNKESPADIQACVGDFLKALIAISANAPLDDISIGPNSLTRQLASPESIAKLVDIMINQRGAALNTTVSIVIELIRKNNSDYDQVNLLTTTIKTHPPSNRDPIYLGYLLRKFSNHLSDFFQIILDIENDANIPLHENQLHEKFKPLGFERFKVVELIAELLHCSNMGLMNSKRAERIARRRDKVRSQLSHHLQDALNDLSIEEKEQLKTKHSPTRDTDHDLKNNNGKIDNDNNDNDDESDYGDEIDESFEIPYINMKQNIKLRTDPTVGDLFKIKLYDTRIVSKIMELFLTHPWNNFWHNVIFDIIQQIFNGRMDFSYNSFLVLSLFNLKSSYQFMTDIVISDEKGTDVSRFSPVIRDPNFDFKITTDFILRGYQDSYKFYELRKMNLGYMGHIVLIAEEVVKFSKLYKVELISPDIQVILQTEEWQYYSEEVLNETRMMYSKILGGGSYIDDGNGNIIPQLPDNTTVLTPNGDASNNNEILDSDTGSSNGTSGGGQLINVESLEEQLSLSTESDLHNKLREMLINRAQEDVDNKNTENGVFILGPPEDKNSNSNINNTNHNSNNSNNNDNNDNNDNDNDNTRNYNEDADNDNDYDHE

Sequence caution

The sequence BAA09279.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias60-99Basic and acidic residues
Compositional bias100-114Polar residues
Compositional bias223-238Acidic residues
Compositional bias239-255Basic and acidic residues
Compositional bias609-636Basic and acidic residues
Sequence conflict663in Ref. 3 and 4; BAA09279
Sequence conflict668in Ref. 2; CAC42243
Sequence conflict674-690in Ref. 1; AA sequence
Sequence conflict815-824in Ref. 1; AAC49303
Compositional bias952-979Polar residues
Compositional bias980-1002Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U50560
EMBL· GenBank· DDBJ
AAC49303.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ318331
EMBL· GenBank· DDBJ
CAC42243.1
EMBL· GenBank· DDBJ
Genomic DNA
D50617
EMBL· GenBank· DDBJ
BAA09279.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
BK006940
EMBL· GenBank· DDBJ
DAA12483.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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