P43586 · LOC1_YEAST
- Protein60S ribosomal subunit assembly/export protein LOC1
- GeneLOC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids204 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for efficient assembly and nuclear export of the 60S ribosomal subunit. Involved in asymmetric localization of ASH1 mRNA.
Miscellaneous
Present with 3650 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Cellular Component | preribosome, large subunit precursor | |
Cellular Component | protein folding chaperone complex | |
Molecular Function | identical protein binding | |
Molecular Function | mRNA binding | |
Biological Process | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | intracellular mRNA localization | |
Biological Process | mRNA transport | |
Biological Process | negative regulation of translation | |
Biological Process | ribosomal large subunit biogenesis | |
Biological Process | ribosomal large subunit export from nucleus |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name60S ribosomal subunit assembly/export protein LOC1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP43586
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000202680 | 1-204 | 60S ribosomal subunit assembly/export protein LOC1 | |||
Sequence: MAPKKPSKRQNLRREVAPEVFQDSQARNQLANVPHLTEKSAQRKPSKTKVKKEQSLARLYGAKKDKKGKYSEKDLNIPTLNRAIVPGVKIRRGKKGKKFIADNDTLTLNRLITTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEALKQDKLEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVKKVSFAQ | ||||||
Modified residue | 24 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Component of the 66S pre-ribosomal particle. Interacts with NOP7, RRP1, RRP15 and SHE2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P43586 | BRX1 Q08235 | 4 | EBI-22906, EBI-3775 | |
BINARY | P43586 | DBP10 Q12389 | 6 | EBI-22906, EBI-5644 | |
BINARY | P43586 | DRS1 P32892 | 5 | EBI-22906, EBI-6170 | |
BINARY | P43586 | EBP2 P36049 | 7 | EBI-22906, EBI-6289 | |
BINARY | P43586 | FPR3 P38911 | 4 | EBI-22906, EBI-6951 | |
BINARY | P43586 | FPR4 Q06205 | 4 | EBI-22906, EBI-6956 | |
BINARY | P43586 | HAS1 Q03532 | 6 | EBI-22906, EBI-8170 | |
BINARY | P43586 | LOC1 P43586 | 3 | EBI-22906, EBI-22906 | |
BINARY | P43586 | MAK21 Q12176 | 3 | EBI-22906, EBI-10944 | |
BINARY | P43586 | MAK5 P38112 | 3 | EBI-22906, EBI-10394 | |
BINARY | P43586 | NOC2 P39744 | 7 | EBI-22906, EBI-29259 | |
BINARY | P43586 | NOG1 Q02892 | 5 | EBI-22906, EBI-12105 | |
BINARY | P43586 | NOP12 Q08208 | 4 | EBI-22906, EBI-35895 | |
BINARY | P43586 | NOP16 P40007 | 3 | EBI-22906, EBI-22439 | |
BINARY | P43586 | NOP4 P37838 | 5 | EBI-22906, EBI-12122 | |
BINARY | P43586 | NOP53 Q12080 | 3 | EBI-22906, EBI-29395 | |
BINARY | P43586 | NUG1 P40010 | 5 | EBI-22906, EBI-22449 | |
BINARY | P43586 | PRP43 P53131 | 3 | EBI-22906, EBI-505 | |
BINARY | P43586 | RRP12 Q12754 | 3 | EBI-22906, EBI-30678 | |
BINARY | P43586 | RRP14 P36080 | 4 | EBI-22906, EBI-26762 | |
BINARY | P43586 | SPB1 P25582 | 5 | EBI-22906, EBI-17814 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-56 | Disordered | ||||
Sequence: MAPKKPSKRQNLRREVAPEVFQDSQARNQLANVPHLTEKSAQRKPSKTKVKKEQSL | ||||||
Compositional bias | 22-36 | Polar residues | ||||
Sequence: QDSQARNQLANVPHL | ||||||
Compositional bias | 40-56 | Basic and acidic residues | ||||
Sequence: SAQRKPSKTKVKKEQSL | ||||||
Coiled coil | 120-166 | |||||
Sequence: DDIAESKLEKARRLEEIRELKRKEIERKEALKQDKLEEKKDEIKKKS | ||||||
Compositional bias | 155-198 | Basic and acidic residues | ||||
Sequence: LEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVK | ||||||
Region | 155-204 | Disordered | ||||
Sequence: LEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVKKVSFAQ |
Sequence similarities
Belongs to the LOC1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length204
- Mass (Da)23,590
- Last updated1995-11-01 v1
- Checksum69970294E9C980F9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 22-36 | Polar residues | ||||
Sequence: QDSQARNQLANVPHL | ||||||
Compositional bias | 40-56 | Basic and acidic residues | ||||
Sequence: SAQRKPSKTKVKKEQSL | ||||||
Compositional bias | 155-198 | Basic and acidic residues | ||||
Sequence: LEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D50617 EMBL· GenBank· DDBJ | BAA09240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY557809 EMBL· GenBank· DDBJ | AAS56135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006940 EMBL· GenBank· DDBJ | DAA12441.1 EMBL· GenBank· DDBJ | Genomic DNA |