P43555 · EMP47_YEAST

Function

function

Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing. Required for the endoplasmic reticulum exit of EMP46.

Miscellaneous

Present with 2900 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCOPII-coated ER to Golgi transport vesicle
Cellular Componentendoplasmic reticulum membrane
Cellular Componentendoplasmic reticulum-Golgi intermediate compartment
Cellular Componentfungal-type vacuole membrane
Cellular ComponentGolgi membrane
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-mannose binding
Biological Processendoplasmic reticulum to Golgi vesicle-mediated transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein EMP47
  • Alternative names
    • 47 kDa endomembrane protein
    • Endosomal P44 protein

Gene names

    • Name
      EMP47
    • Ordered locus names
      YFL048C

Organism names

Accessions

  • Primary accession
    P43555
  • Secondary accessions
    • D6VTI2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-412Lumenal
Transmembrane413-433Helical
Topological domain434-445Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_000002117329-445Protein EMP47
Disulfide bond179↔213

Keywords

Proteomic databases

Interaction

Subunit

Homooligomers. Interacts with EMP46 in the endoplasmic reticulum membrane. Interacts with the coatomer proteins COP1, SEC21 and SEC23.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P43555EMP46 Q123964EBI-6439, EBI-38641

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, motif.

TypeIDPosition(s)Description
Domain36-254L-type lectin-like
Region430-433Mediates the interactions with COPI and COPII coat complexes
Motif441-445Di-lysine motif

Domain

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

Sequence similarities

Belongs to the EMP46/EMP47 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    445
  • Mass (Da)
    50,330
  • Last updated
    1995-11-01 v1
  • Checksum
    3978462BC2AFCD8A
MMMLITMKSTVLLSVFTVLATWAGLLEAHPLGDTSDASKLSSDYSLPDLINARKVPNNWQTGEQASLEEGRIVLTSKQNSKGSLWLKQGFDLKDSFTMEWTFRSVGYSGQTDGGISFWFVQDSNVPRDKQLYNGPVNYDGLQLLVDNNGPLGPTLRGQLNDGQKPVDKTKIYDQSFASCLMGYQDSSVPSTIRVTYDLEDDNLLKVQVDNKVCFQTRKVRFPSGSYRIGVTAQNGAVNNNAESFEIFKMQFFNGVIEDSLIPNVNAMGQPKLITKYIDQQTGKEKLIEKTAFDADKDKITNYELYKKLDRVEGKILANDINALETKLNDVIKVQQELLSFMTTITKQLSSKPPANNEKGTSTDDAIAEDKENFKDFLSINQKLEKVLVEQEKYREATKRHGQDGPQVDEIARKLMIWLLPLIFIMLVMAYYTFRIRQEIIKTKLL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict52in Ref. 1; CAA60953
Sequence conflict77in Ref. 1; CAA60953
Sequence conflict125in Ref. 1; CAA60953

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X87622
EMBL· GenBank· DDBJ
CAA60953.1
EMBL· GenBank· DDBJ
Genomic DNA
D50617
EMBL· GenBank· DDBJ
BAA09193.1
EMBL· GenBank· DDBJ
Genomic DNA
AY693033
EMBL· GenBank· DDBJ
AAT93052.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006940
EMBL· GenBank· DDBJ
DAA12392.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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