P43524 · CYAA_ANACY

  • Protein
    Adenylate cyclase
  • Gene
    cya
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

May function as a membrane-localized receptor protein.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site.

150250100150200250300350400450500
TypeIDPosition(s)Description
Binding site325Mg2+ (UniProtKB | ChEBI)
Binding site369Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane-derived thylakoid membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate cyclase
  • EC number
  • Alternative names
    • ATP pyrophosphate-lyase
    • Adenylyl cyclase

Gene names

    • Name
      cya

Organism names

  • Taxonomic identifier
  • Strain
    • IAM M-1
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Anabaena

Accessions

  • Primary accession
    P43524

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-25Cytoplasmic
Transmembrane26-46Helical
Topological domain47-203Lumenal, thylakoid
Transmembrane204-226Helical
Topological domain227-502Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001957421-502Adenylate cyclase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain227-280HAMP
Domain320-451Guanylate cyclase

Domain

The N-terminal half could sense signals such as pH or a change in membrane potential and regulates the catalytic activity of the C-terminal half.

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    502
  • Mass (Da)
    55,294
  • Last updated
    1995-11-01 v1
  • Checksum
    C61023B37CD8C4E9
MGDFCRRVDCKAMKFFALRSSIRTQIMASTTLLILALIGAIVTVWAKSESTLYHQEKLNDAKILSKVLSSTYANEVSEENWSQIRLNIDLLLRENEDFLYALVSDSNQKNQIAASSPDEFQNNYIPDIVSLSVTNAAINSSEKTHVVETFILRDIYFADKLRAKRGEKVMEVSSDIQTLSGRKLGKLRIGISLRKVNLAVTNAVNQALVVGFAGLNIGWICAYFLAQHLSDPVRRLQISVAKIAGGDLQHRADIHSRADEIGALATSVNEMSAALQISFNKLKKTLDSFERFVPNKFISVIAPQGIENIEVGAASTRRMTILFCDIRGYTSMSEAMEPIEIFRFLNDYLACMGKAIDEAGGFIDKYIGDAIMALFDDGNTDCALHAAILMQQALDKFNDERSMQTGKTGLPRISVGIGIHRGTVVMGTVGFTSRIDSTVIGDAVNVASRIEGLTKQYGCNILITESVVRNLSCPESFSLRLIDKSVKVKGKDEAISIYEVKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D55650
EMBL· GenBank· DDBJ
BAA09511.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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