P43524 · CYAA_ANACY
- ProteinAdenylate cyclase
- Genecya
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids502 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
May function as a membrane-localized receptor protein.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane-derived thylakoid membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate cyclase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Anabaena
Accessions
- Primary accessionP43524
Subcellular Location
UniProt Annotation
GO Annotation
Cellular thylakoid membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-25 | Cytoplasmic | ||||
Sequence: MGDFCRRVDCKAMKFFALRSSIRTQ | ||||||
Transmembrane | 26-46 | Helical | ||||
Sequence: IMASTTLLILALIGAIVTVWA | ||||||
Topological domain | 47-203 | Lumenal, thylakoid | ||||
Sequence: KSESTLYHQEKLNDAKILSKVLSSTYANEVSEENWSQIRLNIDLLLRENEDFLYALVSDSNQKNQIAASSPDEFQNNYIPDIVSLSVTNAAINSSEKTHVVETFILRDIYFADKLRAKRGEKVMEVSSDIQTLSGRKLGKLRIGISLRKVNLAVTNA | ||||||
Transmembrane | 204-226 | Helical | ||||
Sequence: VNQALVVGFAGLNIGWICAYFLA | ||||||
Topological domain | 227-502 | Cytoplasmic | ||||
Sequence: QHLSDPVRRLQISVAKIAGGDLQHRADIHSRADEIGALATSVNEMSAALQISFNKLKKTLDSFERFVPNKFISVIAPQGIENIEVGAASTRRMTILFCDIRGYTSMSEAMEPIEIFRFLNDYLACMGKAIDEAGGFIDKYIGDAIMALFDDGNTDCALHAAILMQQALDKFNDERSMQTGKTGLPRISVGIGIHRGTVVMGTVGFTSRIDSTVIGDAVNVASRIEGLTKQYGCNILITESVVRNLSCPESFSLRLIDKSVKVKGKDEAISIYEVKA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000195742 | 1-502 | Adenylate cyclase | |||
Sequence: MGDFCRRVDCKAMKFFALRSSIRTQIMASTTLLILALIGAIVTVWAKSESTLYHQEKLNDAKILSKVLSSTYANEVSEENWSQIRLNIDLLLRENEDFLYALVSDSNQKNQIAASSPDEFQNNYIPDIVSLSVTNAAINSSEKTHVVETFILRDIYFADKLRAKRGEKVMEVSSDIQTLSGRKLGKLRIGISLRKVNLAVTNAVNQALVVGFAGLNIGWICAYFLAQHLSDPVRRLQISVAKIAGGDLQHRADIHSRADEIGALATSVNEMSAALQISFNKLKKTLDSFERFVPNKFISVIAPQGIENIEVGAASTRRMTILFCDIRGYTSMSEAMEPIEIFRFLNDYLACMGKAIDEAGGFIDKYIGDAIMALFDDGNTDCALHAAILMQQALDKFNDERSMQTGKTGLPRISVGIGIHRGTVVMGTVGFTSRIDSTVIGDAVNVASRIEGLTKQYGCNILITESVVRNLSCPESFSLRLIDKSVKVKGKDEAISIYEVKA |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 227-280 | HAMP | ||||
Sequence: QHLSDPVRRLQISVAKIAGGDLQHRADIHSRADEIGALATSVNEMSAALQISFN | ||||||
Domain | 320-451 | Guanylate cyclase | ||||
Sequence: TILFCDIRGYTSMSEAMEPIEIFRFLNDYLACMGKAIDEAGGFIDKYIGDAIMALFDDGNTDCALHAAILMQQALDKFNDERSMQTGKTGLPRISVGIGIHRGTVVMGTVGFTSRIDSTVIGDAVNVASRIE |
Domain
The N-terminal half could sense signals such as pH or a change in membrane potential and regulates the catalytic activity of the C-terminal half.
Sequence similarities
Belongs to the adenylyl cyclase class-3 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length502
- Mass (Da)55,294
- Last updated1995-11-01 v1
- ChecksumC61023B37CD8C4E9