P43117 · PF2R_MOUSE
- ProteinProstaglandin F2-alpha receptor
- GenePtgfr
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids366 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | prostaglandin F receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | cellular response to prostaglandin D stimulus | |
Biological Process | inflammatory response | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | positive regulation of gene expression | |
Biological Process | response to estradiol | |
Biological Process | response to lipopolysaccharide |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin F2-alpha receptor
- Short namesPGF receptor; PGF2-alpha receptor
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP43117
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Extracellular | ||||
Sequence: MSMNSSKQPVSPAAGLIANTTCQTENRLSVF | ||||||
Transmembrane | 32-55 | Helical; Name=1 | ||||
Sequence: FSIIFMTVGILSNSLAIAILMKAY | ||||||
Topological domain | 56-69 | Cytoplasmic | ||||
Sequence: QRFRQKSKASFLLL | ||||||
Transmembrane | 70-90 | Helical; Name=2 | ||||
Sequence: ASGLVITDFFGHLINGGIAVF | ||||||
Topological domain | 91-109 | Extracellular | ||||
Sequence: VYASDKDWIRFDQSNILCS | ||||||
Transmembrane | 110-131 | Helical; Name=3 | ||||
Sequence: IFGISMVFSGLCPLFLGSAMAI | ||||||
Topological domain | 132-152 | Cytoplasmic | ||||
Sequence: ERCIGVTNPIFHSTKITSKHV | ||||||
Transmembrane | 153-175 | Helical; Name=4 | ||||
Sequence: KMILSGVCMFAVFVAVLPILGHR | ||||||
Topological domain | 176-198 | Extracellular | ||||
Sequence: DYQIQASRTWCFYNTEHIEDWED | ||||||
Transmembrane | 199-224 | Helical; Name=5 | ||||
Sequence: RFYLLFFSFLGLLALGVSFSCNAVTG | ||||||
Topological domain | 225-250 | Cytoplasmic | ||||
Sequence: VTLLRVKFRSQQHRQGRSHHLEMIIQ | ||||||
Transmembrane | 251-267 | Helical; Name=6 | ||||
Sequence: LLAIMCVSCVCWSPFLV | ||||||
Topological domain | 268-285 | Extracellular | ||||
Sequence: TMANIAINGNNSPVTCET | ||||||
Transmembrane | 286-307 | Helical; Name=7 | ||||
Sequence: TLFALRMATWNQILDPWVYILL | ||||||
Topological domain | 308-366 | Cytoplasmic | ||||
Sequence: RKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070071 | 1-366 | Prostaglandin F2-alpha receptor | |||
Sequence: MSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL | ||||||
Glycosylation | 4 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 19 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 108↔186 | |||||
Sequence: CSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length366
- Mass (Da)40,700
- Last updated1995-11-01 v1
- ChecksumB01CB3B271007582
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D17433 EMBL· GenBank· DDBJ | BAA04251.1 EMBL· GenBank· DDBJ | mRNA | ||
AK087833 EMBL· GenBank· DDBJ | BAC40021.1 EMBL· GenBank· DDBJ | mRNA | ||
BC064794 EMBL· GenBank· DDBJ | AAH64794.1 EMBL· GenBank· DDBJ | mRNA |