P43114 · PE2R4_RAT

  • Protein
    Prostaglandin E2 receptor EP4 subtype
  • Gene
    Ptger4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Caution

Was originally designated as the EP2 subtype.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentneuron projection terminus
Cellular Componentneuronal cell body
Cellular Componentnuclear membrane
Cellular Componentplasma membrane
Molecular Functionprostaglandin E receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Processbone development
Biological Processcellular response to glucose stimulus
Biological Processcellular response to interleukin-1
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to prostaglandin E stimulus
Biological Processchemokinesis
Biological Processductus arteriosus closure
Biological ProcessERK1 and ERK2 cascade
Biological Processfemale pregnancy
Biological Processimmune response
Biological Processinflammatory response
Biological ProcessJNK cascade
Biological Processmaternal process involved in parturition
Biological Processnegative regulation of cytokine production
Biological Processnegative regulation of ductus arteriosus closure
Biological Processnegative regulation of endothelin production
Biological Processnegative regulation of eosinophil extravasation
Biological Processnegative regulation of hydrogen peroxide metabolic process
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of integrin activation
Biological Processnegative regulation of interleukin-1 alpha production
Biological Processnegative regulation of nitric-oxide synthase biosynthetic process
Biological Processnegative regulation of peptide secretion
Biological Processnegative regulation of small intestine smooth muscle contraction
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpositive regulation of antral ovarian follicle growth
Biological Processpositive regulation of bone resorption
Biological Processpositive regulation of calcitonin secretion
Biological Processpositive regulation of cAMP-mediated signaling
Biological Processpositive regulation of cell adhesion
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of chemokinesis
Biological Processpositive regulation of circadian sleep/wake cycle, non-REM sleep
Biological Processpositive regulation of cytokine production
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of hyaluronan biosynthetic process
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interleukin-10 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of matrix metallopeptidase secretion
Biological Processpositive regulation of mucus secretion
Biological Processpositive regulation of neutrophil extravasation
Biological Processpositive regulation of ossification
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of ovarian follicle development
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of protein secretion
Biological Processpositive regulation of smooth muscle cell migration
Biological Processpositive regulation of substance P secretion
Biological Processpositive regulation of substance P secretion, neurotransmission
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processpositive regulation of urine volume
Biological Processpositive regulation of wound healing
Biological Processregulation of circadian sleep/wake cycle, wakefulness
Biological Processregulation of ossification
Biological Processregulation of stress fiber assembly
Biological Processresponse to amino acid
Biological Processresponse to interleukin-1
Biological Processresponse to lipopolysaccharide
Biological Processresponse to mechanical stimulus
Biological Processresponse to nematode
Biological Processresponse to organic cyclic compound
Biological Processresponse to progesterone
Biological Processresponse to prostaglandin E
Biological Processresponse to salt
Biological Processresponse to water-immersion restraint stress
Biological Processresponse to xenobiotic stimulus
Biological ProcessT-helper cell differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin E2 receptor EP4 subtype
  • Short names
    PGE receptor EP4 subtype; PGE2 receptor EP4 subtype
  • Alternative names
    • Prostanoid EP4 receptor

Gene names

    • Name
      Ptger4

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P43114
  • Secondary accessions
    • O08728

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-19Extracellular
Transmembrane20-43Helical; Name=1
Topological domain44-55Cytoplasmic
Transmembrane56-79Helical; Name=2
Topological domain80-96Extracellular
Transmembrane97-115Helical; Name=3
Topological domain116-135Cytoplasmic
Transmembrane136-160Helical; Name=4
Topological domain161-184Extracellular
Transmembrane185-211Helical; Name=5
Topological domain212-270Cytoplasmic
Transmembrane271-298Helical; Name=6
Topological domain299-315Extracellular
Transmembrane316-335Helical; Name=7
Topological domain336-488Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000700681-488Prostaglandin E2 receptor EP4 subtype
Glycosylation7N-linked (GlcNAc...) asparagine
Disulfide bond92↔170
Modified residue377Phosphoserine
Modified residue380Phosphoserine
Modified residue382Phosphoserine
Modified residue385Phosphoserine

Post-translational modification

Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with FEM1A.

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region358-380Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    53,366
  • Last updated
    1995-11-01 v1
  • Checksum
    C2EE713018723FF4
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2JSM6A0A0G2JSM6_RATPtger4488

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict214in Ref. 2; AAB53326
Sequence conflict396in Ref. 2; AAB53326

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D28860
EMBL· GenBank· DDBJ
BAA06011.1
EMBL· GenBank· DDBJ
mRNA
U94709
EMBL· GenBank· DDBJ
AAB53326.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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