P43072 · TF3B_CANAL

Function

function

General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.

Features

Showing features for binding site.

155350100150200250300350400450500550
TypeIDPosition(s)Description
Binding site10Zn2+ (UniProtKB | ChEBI)
Binding site13Zn2+ (UniProtKB | ChEBI)
Binding site31Zn2+ (UniProtKB | ChEBI)
Binding site34Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription factor TFIIIB complex
Cellular Componenttranscription preinitiation complex
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase III core binding
Molecular FunctionRNA polymerase III general transcription initiation factor activity
Molecular FunctionRNA polymerase III type 3 promoter sequence-specific DNA binding
Molecular FunctionTBP-class protein binding
Molecular FunctionTFIIIC-class transcription factor complex binding
Biological ProcessDNA-templated transcription initiation
Biological ProcessDNA-templated transcription open complex formation
Biological Processregulation of transcription by RNA polymerase III
Biological ProcessRNA polymerase III preinitiation complex assembly
Biological Processtranscription by RNA polymerase III
Biological Processtranscription initiation at RNA polymerase III promoter

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor IIIB 70 kDa subunit
  • Short names
    TFIIIB
  • Alternative names
    • B-related factor 1 (BRF-1)

Gene names

    • Name
      TDS4
    • Synonyms
      BRF, BRF1
    • ORF names
      CaO19.13970, CaO19.6649
    • Ordered locus names
      CAALFM_CR05650WA

Organism names

Accessions

  • Primary accession
    P43072
  • Secondary accessions
    • A0A1D8PT19
    • Q59PR5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001193431-553Transcription factor IIIB 70 kDa subunit

Interaction

Subunit

TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and a 70 kDa polypeptide.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, repeat, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger6-39TFIIB-type
Repeat98-1741
Region98-272Interaction with TBP and with the Pol III subunit C34
Repeat193-2722
Region281-553Interaction with TBP
Region473-523Disordered
Compositional bias495-520Basic and acidic residues

Sequence similarities

Belongs to the TFIIB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    553
  • Mass (Da)
    61,840
  • Last updated
    1995-11-01 v1
  • Checksum
    FEC1E270B15EEEC1
MSKPRKQQKCKTCGHTQFDVNRYTAAGDVSCLRCGTVLEENPIVSEVQFGESSSGAAMVQGAMVGADQARATFAGGRQNAMESREQTLSNGKRKIKRIAAALKIPDYIAEAAGEWFRLALTLNFVQGRRSNNVLATCLYVACRKERTHHMLIDFSSRLQISVYSLGATFLKMVKALHITSLPLADPSLFIQHFVEKLDFKDKATKVAKDAVKLAHRMAADWIHEGRRPAGIAGACVLLAARMNNFRRSHAEIVAVSHVGEETLQRRLNEFKKTKAGTLSVKSFREVENLESSNPPSFEKNRAMELKISKKLQQQQTDNFEDLSKMTEEEKQSVFGKLSKEEAQKQLLMNTILSDITITTENLNDQMDRILKMKKSSLENSLYKTPYELALANGSEQDPSKIWNINKPKNLVANLPKTDDILQNVSSEVELNSDDDDEIVLESKLTEEEVAIKERIWTGLNHDYLVEQEKKRLKQEADELTGNTSKSSSGNRRKRNKSSLPAELRKELGDIDLDEDGTPRSAADSAKMYISKTSVSKKINYDSLKGLLGGNMGF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias495-520Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z47202
EMBL· GenBank· DDBJ
CAA87398.1
EMBL· GenBank· DDBJ
Genomic DNA
CP017630
EMBL· GenBank· DDBJ
AOW31281.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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