P43057 · KPC1_CANAX
- ProteinProtein kinase C-like 1
- GenePKC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1097 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Necessary for osmotic stability.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic stress granule | |
Cellular Component | cytoskeleton | |
Cellular Component | nucleus | |
Cellular Component | site of polarized growth | |
Molecular Function | ATP binding | |
Molecular Function | diacylglycerol-dependent serine/threonine kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Biological Process | cellular bud neck septin ring organization | |
Biological Process | fungal-type cell wall biogenesis | |
Biological Process | intracellular signal transduction | |
Biological Process | pexophagy | |
Biological Process | positive regulation of cytoplasmic mRNA processing body assembly | |
Biological Process | regulation of fungal-type cell wall organization | |
Biological Process | regulation of nuclear-transcribed mRNA poly(A) tail shortening | |
Biological Process | stress granule assembly |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein kinase C-like 1
- EC number
- Short namesPKC 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionP43057
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000055739 | 1-1097 | Protein kinase C-like 1 | |||
Sequence: MSTSQPSQQQNPEQVVNDIRQKIEKERKIIQGFNDVKRNTNNPEVIQKWKSKIIESQSMIDYYQETMNKLTRQMQRLNTNSSSRTASRSSVISEYKPSYSNFDLIKYECPSLGNKIQFMLQYLEFKLQVENKYSEANKKLSHLYLMDGDKSSSNAAEGGRAESDQRIQLLEKALKKYQKFSINDHEFDRDYEIMDSTKHSRKLLTGRLTVSITCIRDVDHIATALAKKRETVVVIKVDDLEKARTKPSKNDNWNEEMVIDVDKSHEIELAVMDKQNGIYVPVAVNWFSLFDLAEEIRKKKVAKDQGSSGWLPAANLPQTGGSGAGTGSSMTGGASYGATSPLPAHNDLRPSVSPSSDAKENKVSVSTWLSLEPGGQMLINLNFEKSITNGKQFRGPLGRHGAIRQKKEEVFEKHGHQFVQKQFYNIMSCALCGEFLRYTGYQCQDCKFLCHKKCYQKVVTKCISKSGSDYDAAQLNHRIPHRFEPITNHGTKWCCHCGYILPWGKKNVRKCTECGVMCHAQCTHLVPDFCGMSLQMANEILATIESTKVSPKKAQHQQSHAKPLPPKPPIESKPSMDSEETLHNEPSYKSLRPASVVHQDTNFVSKLPTTVQNKYQEPVELPPQQQNQVVPSTRRRGHGSTDLSFETGYGQQQHQHHRDVPQIVVEDHQHYNSNDNRDVEMEESKDEFDNFDYNNKYTENEILTDVQQDQVRSPFADQIQGVPETSHAKQQNQQVQQVQQQEELGHQRTHSSGKSGKSKRRKRKVGLDDFQFLAVLGKGNFGKVMLAESRHTSKLCAIKVLKKDFIVENDEAESVKSEKRVFLTANKEMHPFLLNLHCCFQTENRIYFVMEYISGGDLMWHIQKNRFTAKRAKFYACEVLLGLKYFHDNGIVYRDLKLDNILLTTKGHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAFGVLLFQMLLCQSPFKGDDEDDIFNAIENDEVKYPINLSRQTVLVLQALLTKDPSQRLGSGPKDAEEIMEHPYFHDVNFDDVLNCRIPAPYIPEVQSEHDYSNFDKEFTSETPRLTPVETVLTSEMQEQFRGFSHISDNATI |
Keywords
- PTM
Interaction
Chemistry
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-76 | REM-1 1 | ||||
Sequence: STSQPSQQQNPEQVVNDIRQKIEKERKIIQGFNDVKRNTNNPEVIQKWKSKIIESQSMIDYYQETMNKLTRQMQR | ||||||
Domain | 106-183 | REM-1 2 | ||||
Sequence: KYECPSLGNKIQFMLQYLEFKLQVENKYSEANKKLSHLYLMDGDKSSSNAAEGGRAESDQRIQLLEKALKKYQKFSIN | ||||||
Domain | 189-311 | C2 | ||||
Sequence: RDYEIMDSTKHSRKLLTGRLTVSITCIRDVDHIATALAKKRETVVVIKVDDLEKARTKPSKNDNWNEEMVIDVDKSHEIELAVMDKQNGIYVPVAVNWFSLFDLAEEIRKKKVAKDQGSSGWL | ||||||
Region | 304-359 | Disordered | ||||
Sequence: DQGSSGWLPAANLPQTGGSGAGTGSSMTGGASYGATSPLPAHNDLRPSVSPSSDAK | ||||||
Compositional bias | 311-336 | Polar residues | ||||
Sequence: LPAANLPQTGGSGAGTGSSMTGGASY | ||||||
Zinc finger | 415-462 | Phorbol-ester/DAG-type 1 | ||||
Sequence: GHQFVQKQFYNIMSCALCGEFLRYTGYQCQDCKFLCHKKCYQKVVTKC | ||||||
Zinc finger | 480-530 | Phorbol-ester/DAG-type 2 | ||||
Sequence: PHRFEPITNHGTKWCCHCGYILPWGKKNVRKCTECGVMCHAQCTHLVPDFC | ||||||
Region | 548-594 | Disordered | ||||
Sequence: KVSPKKAQHQQSHAKPLPPKPPIESKPSMDSEETLHNEPSYKSLRPA | ||||||
Region | 615-646 | Disordered | ||||
Sequence: YQEPVELPPQQQNQVVPSTRRRGHGSTDLSFE | ||||||
Compositional bias | 724-746 | Polar residues | ||||
Sequence: ETSHAKQQNQQVQQVQQQEELGH | ||||||
Region | 724-763 | Disordered | ||||
Sequence: ETSHAKQQNQQVQQVQQQEELGHQRTHSSGKSGKSKRRKR | ||||||
Domain | 770-1029 | Protein kinase | ||||
Sequence: FQFLAVLGKGNFGKVMLAESRHTSKLCAIKVLKKDFIVENDEAESVKSEKRVFLTANKEMHPFLLNLHCCFQTENRIYFVMEYISGGDLMWHIQKNRFTAKRAKFYACEVLLGLKYFHDNGIVYRDLKLDNILLTTKGHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAFGVLLFQMLLCQSPFKGDDEDDIFNAIENDEVKYPINLSRQTVLVLQALLTKDPSQRLGSGPKDAEEIMEHPYF | ||||||
Domain | 1030-1097 | AGC-kinase C-terminal | ||||
Sequence: HDVNFDDVLNCRIPAPYIPEVQSEHDYSNFDKEFTSETPRLTPVETVLTSEMQEQFRGFSHISDNATI |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,097
- Mass (Da)125,312
- Last updated1995-11-01 v1
- ChecksumEC48A14575F26CD5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 311-336 | Polar residues | ||||
Sequence: LPAANLPQTGGSGAGTGSSMTGGASY | ||||||
Compositional bias | 724-746 | Polar residues | ||||
Sequence: ETSHAKQQNQQVQQVQQQEELGH |