P43027 · GDF5_MOUSE

  • Protein
    Growth/differentiation factor 5
  • Gene
    Gdf5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity).
Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity).
Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600).
Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular FunctionBMP binding
Molecular Functioncytokine activity
Molecular Functiongrowth factor activity
Molecular Functionidentical protein binding
Molecular Functionsignaling receptor binding
Biological ProcessBMP signaling pathway
Biological Processcell surface receptor protein serine/threonine kinase signaling pathway
Biological Processchondroblast differentiation
Biological Processchondrocyte differentiation
Biological Processembryonic limb morphogenesis
Biological Processforelimb morphogenesis
Biological Processhindlimb morphogenesis
Biological Processmesenchymal cell apoptotic process
Biological Processnegative regulation of chondrocyte differentiation
Biological Processnegative regulation of epithelial cell proliferation
Biological Processnegative regulation of mesenchymal cell apoptotic process
Biological Processnegative regulation of neuron apoptotic process
Biological Processossification involved in bone remodeling
Biological Processpositive regulation of BMP signaling pathway
Biological Processpositive regulation of chondrocyte differentiation
Biological Processpositive regulation of neuron differentiation
Biological Processpositive regulation of SMAD protein signal transduction
Biological Processregulation of multicellular organism growth
Biological Processresponse to mechanical stimulus
Biological ProcessSMAD protein signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Growth/differentiation factor 5
  • Short names
    GDF-5
  • Alternative names
    • Bone morphogenetic protein 14 (BMP-14)

Gene names

    • Name
      Gdf5
    • Synonyms
      Bmp14, Bp, Gdf-5

Organism names

  • Taxonomic identifier
  • Strains
    • CD-1
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P43027
  • Secondary accessions
    • A2ARK2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Involvement in disease

  • Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant98

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-27
PropeptidePRO_000003391428-375
Glycosylation183N-linked (GlcNAc...) asparagine
ChainPRO_0000033915376-495Growth/differentiation factor 5
Disulfide bond394↔460
Disulfide bond423↔492
Disulfide bond427↔494
Disulfide bond459Interchain

Keywords

Proteomic databases

PTM databases

Expression

Induction

Induced over 300-fold in tibialis anterior muscles 3 days following denervation. High expression is maintained at least until 10 days after denervation.

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked (By similarity).
Interacts with serine proteases, HTRA1 and HTRA3 (PubMed:14973287, PubMed:15206957).
Following LPS binding, may form a complex with CXCR4, HSP90AA1 and HSPA8 (By similarity).
Interacts with high affinity with NOG; inhibits chondrogenesis (By similarity).
Interacts with high affinity with BMPR1B and lower affinity with BMPR1A; positively regulates chondrocyte differentiation and induces SMAD-dependent signaling. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region30-162Disordered
Compositional bias80-94Basic and acidic residues
Compositional bias100-115Polar residues

Sequence similarities

Belongs to the TGF-beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    495
  • Mass (Da)
    54,895
  • Last updated
    2011-07-27 v2
  • Checksum
    8FAECD5A9C996D6E
MRLPKLLTLLLWHLAWLDLELICTVLGAPDLGQRTPGAKPGLTKAEAKERPPLARNVFRPGGHIYGVGATNARAKGSSGQTQAKKDEPRKMPPRSGGPETKPGPSSQTRQAAARTVTPKGQLPGGKASSKAGSAPSSFLLKKTREPGTPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPAVRKQRYVFDISALEKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFERTARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias80-94Basic and acidic residues
Compositional bias100-115Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U08337
EMBL· GenBank· DDBJ
AAA18778.1
EMBL· GenBank· DDBJ
mRNA
AL845445
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466551
EMBL· GenBank· DDBJ
EDL06156.1
EMBL· GenBank· DDBJ
Genomic DNA
BC034546
EMBL· GenBank· DDBJ
AAH34546.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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