P42963 · PXPA_BACSU

Function

function

Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Function5-oxoprolinase (ATP-hydrolyzing) activity
Molecular FunctionATP binding
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-oxoprolinase subunit A
  • EC number
  • Short names
    5-OPase subunit A
  • Alternative names
    • 5-oxoprolinase (ATP-hydrolyzing) subunit A

Gene names

    • Name
      pxpA
    • Synonyms
      ycsF
    • Ordered locus names
      BSU04050

Organism names

Accessions

  • Primary accession
    P42963

Proteomes

Phenotypes & Variants

Disruption phenotype

Deletion mutant grows less well than wild type on minimal medium with ammonium as nitrogen source and cannot grow on 5-oxoproline. Mutant lacks 5-oxoprolinase activity and accumulates 5-oxo-L-proline.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001849901-2575-oxoprolinase subunit A

Proteomic databases

Interaction

Subunit

Forms a complex composed of PxpA, PxpB and PxpC.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the LamB/PxpA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    257
  • Mass (Da)
    27,482
  • Last updated
    2009-07-28 v4
  • Checksum
    2799684330644E71
MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPSVMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAEGLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQTANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKADTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST

Sequence caution

The sequence BAA07357.1 differs from that shown. Reason: Frameshift
The sequence BAA09036.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict208in Ref. 1; BAA09036 and 5; BAA07357
Sequence conflict219-224in Ref. 1; BAA09036 and 5; BAA07357

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D50453
EMBL· GenBank· DDBJ
BAA09036.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
AL009126
EMBL· GenBank· DDBJ
CAB12213.3
EMBL· GenBank· DDBJ
Genomic DNA
D38161
EMBL· GenBank· DDBJ
BAA07357.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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