P42685 · FRK_HUMAN

  • Protein
    Tyrosine-protein kinase FRK
  • Gene
    FRK
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Catalytic activity

Features

Showing features for binding site, active site.

150550100150200250300350400450500
TypeIDPosition(s)Description
Binding site240-248ATP (UniProtKB | ChEBI)
Binding site262ATP (UniProtKB | ChEBI)
Active site354Proton acceptor

GO annotations

AspectTerm
Cellular Componentazurophil granule lumen
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentextracellular region
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular Componentspecific granule lumen
Molecular FunctionATP binding
Molecular Functionnon-membrane spanning protein tyrosine kinase activity
Molecular Functionprotein tyrosine kinase activity
Molecular Functionsignaling receptor binding
Biological Processcell differentiation
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processinnate immune response
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase FRK
  • EC number
  • Alternative names
    • FYN-related kinase
    • Nuclear tyrosine protein kinase RAK
    • Protein-tyrosine kinase 5

Gene names

    • Name
      FRK
    • Synonyms
      PTK5, RAK

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P42685
  • Secondary accessions
    • B4DY49
    • Q13128
    • Q9NTR5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_041702100in dbSNP:rs34704018
Natural variantVAR_006283122in dbSNP:rs3756772
Natural variantVAR_041703133in dbSNP:rs34064900
Mutagenesis262Loss of ability to phosphorylate PTEN.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 542 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000880971-505UniProtTyrosine-protein kinase FRK
Modified residue37UniProtPhosphoserine
Modified residue (large scale data)37PRIDEPhosphoserine
Modified residue40UniProtPhosphoserine
Modified residue (large scale data)40PRIDEPhosphoserine
Modified residue (large scale data)46PRIDEPhosphotyrosine
Modified residue (large scale data)132PRIDEPhosphotyrosine
Modified residue178UniProtPhosphothreonine
Modified residue (large scale data)178PRIDEPhosphothreonine
Modified residue387UniProtPhosphotyrosine; by autocatalysis
Modified residue (large scale data)387PRIDEPhosphotyrosine
Modified residue (large scale data)497PRIDEPhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts (via the SH3-domain) with PTEN. Interacts with RB1.

Binary interactions

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain42-110SH3
Domain116-208SH2
Domain234-491Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P42685-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    505
  • Mass (Da)
    58,254
  • Last updated
    1995-11-01 v1
  • Checksum
    06EC050DDBCD930B
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR

P42685-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-13: MSNICQRLWEYLE → MDSTSLLPNPWIR
    • 14-155: Missing

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0564961-13in isoform 2
Alternative sequenceVSP_05649714-155in isoform 2
Sequence conflict115in Ref. 1; AAC50116

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U22322
EMBL· GenBank· DDBJ
AAC50116.1
EMBL· GenBank· DDBJ
mRNA
U00803
EMBL· GenBank· DDBJ
AAA18284.1
EMBL· GenBank· DDBJ
mRNA
AK302264
EMBL· GenBank· DDBJ
BAG63611.1
EMBL· GenBank· DDBJ
mRNA
AL021451
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL121963
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL357141
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471051
EMBL· GenBank· DDBJ
EAW48241.1
EMBL· GenBank· DDBJ
Genomic DNA
BC012916
EMBL· GenBank· DDBJ
AAH12916.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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