P42656 · RAD24_SCHPO
- ProteinCheckpoint signal transducer rad24
- Generad24
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids270 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts in cell cycle and stress checkpoint signaling by sequestering signal transducers regulated by the checkpoints (PubMed:11818066, PubMed:15629716, PubMed:8036497).
Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted (PubMed:8036497).
During environmental stress, sequesters srk1-phosphorylated cdc25 in the cytoplasm to delay the G2/M transition (PubMed:15629716).
Sequesters byr2 in the cytoplasm to prevent its translocation to the plasma membrane (PubMed:12242289).
Sequesters ran1/pat1-phosphorylated mei2 from its non-coding RNA activators (including meiRNA), to prevent meiotic induction in vegetative cells and to regulate meiosis I (PubMed:11818066).
Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted (PubMed:8036497).
During environmental stress, sequesters srk1-phosphorylated cdc25 in the cytoplasm to delay the G2/M transition (PubMed:15629716).
Sequesters byr2 in the cytoplasm to prevent its translocation to the plasma membrane (PubMed:12242289).
Sequesters ran1/pat1-phosphorylated mei2 from its non-coding RNA activators (including meiRNA), to prevent meiotic induction in vegetative cells and to regulate meiosis I (PubMed:11818066).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cell division site | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | mitotic actomyosin contractile ring, distal actin filament layer | |
Cellular Component | mitotic spindle | |
Cellular Component | mitotic spindle midzone | |
Cellular Component | mitotic spindle pole body | |
Cellular Component | nucleus | |
Molecular Function | protein sequestering activity | |
Biological Process | cellular response to heat | |
Biological Process | meiotic cell cycle | |
Biological Process | mitotic cytokinesis checkpoint signaling | |
Biological Process | mitotic DNA replication checkpoint signaling | |
Biological Process | mitotic G2 DNA damage checkpoint signaling | |
Biological Process | negative regulation of induction of conjugation with cellular fusion | |
Biological Process | protein localization | |
Biological Process | signal transduction |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCheckpoint signal transducer rad24
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionP42656
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
Homodimer (PubMed:12242289).
Binds preferentially to mei2 phosphorylated by ran1/pat1 (PubMed:11818066).
Binds preferentially to cdc25 phosphorylated by srk1 during G2; the interaction is increased during osmotic stress (PubMed:15629716).
Interacts with byr2 (PubMed:12242289).
Interacts with rad25 (PubMed:12242289).
Binds preferentially to mei2 phosphorylated by ran1/pat1 (PubMed:11818066).
Binds preferentially to cdc25 phosphorylated by srk1 during G2; the interaction is increased during osmotic stress (PubMed:15629716).
Interacts with byr2 (PubMed:12242289).
Interacts with rad25 (PubMed:12242289).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P42656 | clp1 Q9P7H1 | 3 | EBI-704791, EBI-704737 |
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)30,082
- Last updated1998-07-15 v2
- Checksum1401DD425A1A872F
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 219 | in Ref. 2; BAA24800 | |||
Sequence conflict | 264 | in Ref. 1; CAA55795 | |||
Sequence conflict | 269-270 | in Ref. 1; CAA55795 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X79206 EMBL· GenBank· DDBJ | CAA55795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010899 EMBL· GenBank· DDBJ | BAA24800.1 EMBL· GenBank· DDBJ | mRNA | ||
AB008545 EMBL· GenBank· DDBJ | BAA28672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CU329670 EMBL· GenBank· DDBJ | CAA17023.1 EMBL· GenBank· DDBJ | Genomic DNA |