P42519 · STAR_DROME
- ProteinProtein Star
- GeneS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids597 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Involved in EGF receptor signaling. Has an early role in photoreceptor development. Interacts with the receptor torpedo in the eye.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein Star
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP42519
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Golgi apparatus membrane ; Single-pass type II membrane protein
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-279 | Cytoplasmic | ||||
Sequence: MSQQVFSAHPALAVDQLQQAEQEEHNTSSNHHQQRSATQSRRHTKAAPKKFTLSRSCAGGGSGTLSGVHQQVKPSPSNPAISPECRKTLPVRTNYAAVDDDDDIECEDVDEVNFGQQEKERERETRQPTKDCGTDETDHVQQRHKNTMTTSATAASRHHHQDGGGGDQSDLSSVISSPSVSTVSSPLSTPTRLPQALQQQLHCCQKSTGMESRARTSPQQIQHPHRQHHQQQHHHHHHHHHLTAAGCTGGGGGGGGSGGSGSCKAKKLDPRLNPSPYRQ | ||||||
Transmembrane | 280-300 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: LLPIALCLLSFAAVFATLIVY | ||||||
Topological domain | 301-597 | Lumenal | ||||
Sequence: MDTTEIRHQQFRLNMSRDYELNGVAQDDPALIDFLRQIHMGKYLGKASPKVAAAASVGVGPPPNSPRLAAAGSTFGSGNSSGSGADQLAHYVADLVGGKMNGAVIQSLSGPLAHLITAPWLSEQLNWMGVLVEPEPRWYFTLRKQNAQRARMQVVHACVSPNTYPKEITIHNEDVRINSLHDEETSWFNSRVKCFPLYTIMLACERTEYDLLSLGVQGHELEILQTLPFDKVKIDVISIHLLEDHEDVADYVLDITRFLAGKSYKLQRKIGRNYFYQRLNASASRTRKKDILLLKTP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000072241 | 1-597 | Protein Star | |||
Sequence: MSQQVFSAHPALAVDQLQQAEQEEHNTSSNHHQQRSATQSRRHTKAAPKKFTLSRSCAGGGSGTLSGVHQQVKPSPSNPAISPECRKTLPVRTNYAAVDDDDDIECEDVDEVNFGQQEKERERETRQPTKDCGTDETDHVQQRHKNTMTTSATAASRHHHQDGGGGDQSDLSSVISSPSVSTVSSPLSTPTRLPQALQQQLHCCQKSTGMESRARTSPQQIQHPHRQHHQQQHHHHHHHHHLTAAGCTGGGGGGGGSGGSGSCKAKKLDPRLNPSPYRQLLPIALCLLSFAAVFATLIVYMDTTEIRHQQFRLNMSRDYELNGVAQDDPALIDFLRQIHMGKYLGKASPKVAAAASVGVGPPPNSPRLAAAGSTFGSGNSSGSGADQLAHYVADLVGGKMNGAVIQSLSGPLAHLITAPWLSEQLNWMGVLVEPEPRWYFTLRKQNAQRARMQVVHACVSPNTYPKEITIHNEDVRINSLHDEETSWFNSRVKCFPLYTIMLACERTEYDLLSLGVQGHELEILQTLPFDKVKIDVISIHLLEDHEDVADYVLDITRFLAGKSYKLQRKIGRNYFYQRLNASASRTRKKDILLLKTP |
Proteomic databases
Expression
Tissue specificity
In the larval eye disk, expression is first seen at the morphogenetic furrow, then in the developing R2, R5, and R8 cells as well as in the posterior clusters of the disk in additional R cells.
Developmental stage
Expressed in embryos and larvae.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-85 | Disordered | ||||
Sequence: MSQQVFSAHPALAVDQLQQAEQEEHNTSSNHHQQRSATQSRRHTKAAPKKFTLSRSCAGGGSGTLSGVHQQVKPSPSNPAISPEC | ||||||
Compositional bias | 57-82 | Polar residues | ||||
Sequence: CAGGGSGTLSGVHQQVKPSPSNPAIS | ||||||
Region | 111-267 | Disordered | ||||
Sequence: EVNFGQQEKERERETRQPTKDCGTDETDHVQQRHKNTMTTSATAASRHHHQDGGGGDQSDLSSVISSPSVSTVSSPLSTPTRLPQALQQQLHCCQKSTGMESRARTSPQQIQHPHRQHHQQQHHHHHHHHHLTAAGCTGGGGGGGGSGGSGSCKAKK | ||||||
Compositional bias | 112-143 | Basic and acidic residues | ||||
Sequence: VNFGQQEKERERETRQPTKDCGTDETDHVQQR | ||||||
Compositional bias | 166-225 | Polar residues | ||||
Sequence: GDQSDLSSVISSPSVSTVSSPLSTPTRLPQALQQQLHCCQKSTGMESRARTSPQQIQHPH | ||||||
Compositional bias | 226-243 | Basic residues | ||||
Sequence: RQHHQQQHHHHHHHHHLT |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length597
- Mass (Da)65,818
- Last updated1995-11-01 v1
- Checksum46B0A2F18B14486B
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A4UZY2 | A4UZY2_DROME | S | 597 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 57-82 | Polar residues | ||||
Sequence: CAGGGSGTLSGVHQQVKPSPSNPAIS | ||||||
Compositional bias | 112-143 | Basic and acidic residues | ||||
Sequence: VNFGQQEKERERETRQPTKDCGTDETDHVQQR | ||||||
Compositional bias | 166-225 | Polar residues | ||||
Sequence: GDQSDLSSVISSPSVSTVSSPLSTPTRLPQALQQQLHCCQKSTGMESRARTSPQQIQHPH | ||||||
Compositional bias | 226-243 | Basic residues | ||||
Sequence: RQHHQQQHHHHHHHHHLT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L31886 EMBL· GenBank· DDBJ | AAB04161.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF51425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY113201 EMBL· GenBank· DDBJ | AAM29206.1 EMBL· GenBank· DDBJ | mRNA |