P41830 · CNR14_CAEEL

  • Protein
    Steroid hormone receptor family member cnr14
  • Gene
    sex-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways (PubMed:16139225, PubMed:17720939, PubMed:21471153, PubMed:23666922, PubMed:33372658).
Directly binds to five 5'-A(G/C)(G/T)(T/G)C(A/G)-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development (PubMed:23666922).
Together with fox-1 is involved in making the distinction between one and two X-chromosomes (PubMed:21471153, PubMed:23666922, PubMed:33372658).
Plays a role in the fox-1-mediated repression of the functionally active isoform (isoform b) of the sex-determining factor xol-1 gene to promote hermaphrodite development (PubMed:33372658).
Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes (PubMed:16139225, PubMed:17720939).

Features

Showing features for dna binding.

153450100150200250300350400450500
TypeIDPosition(s)Description
DNA binding148-223Nuclear receptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionnuclear receptor activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processcell differentiation
Biological Processdosage compensation by hypoactivation of X chromosome
Biological Processhormone-mediated signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprimary sex determination
Biological Processregulation of alternative mRNA splicing, via spliceosome
Biological Processsex differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Steroid hormone receptor family member cnr14
  • Alternative names
    • Nuclear receptor subfamily 1 group G member 1

Gene names

    • Name
      sex-1
    • Synonyms
      cnr-14
      , nhr-24
      , nr1g1
    • ORF names
      F44A6.2

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P41830

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown results in 43% lethality of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown together with fox-1 results in hermaphrodite embryonic lethality (PubMed:21471153, PubMed:33372658).
This hermaphrodite-specific lethality is suppressed in a sea-2 bp283 mutant or sea-1 gk799 mutant background (PubMed:21471153).
RNAi-mediated knockdown results in hermaphrodites lethality due to failure of the dosage compensation complex to assemble on X chromosomes in a fox-1 y303 mutant background (PubMed:17720939).
RNAi-mediated knockdown in a background containing one copy of the fox-1 gene results in the viability of 3% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of the xol-1 gene have been mutated to AUACA and AUAUA, respectively results in the viability of 1% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUACA and AUAUA, respectively results in the viability of 7% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCACG motifs in intron 6 of the xol-1 gene have been mutated to AUACA results in the viability of 24% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCACG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUACA results in the viability of 18% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCUAG motifs in intron 6 of the xol-1 gene have been mutated to AUAUA results in the viability of 33% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUAUA results in the viability of 13% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of the xol-1 gene have been mutated to GCUUG results in the viability of 8% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to GCUUG results in the viability of 36% of hermaphrodites (PubMed:33372658).
RNAi-mediated knockdown in strains containing five or three fox-1-binding GCACG motifs in intron 6 of the xol-1 gene results in the viability of 49% and 33% of hermaphrodites, respectively (PubMed:33372658).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000535231-534Steroid hormone receptor family member cnr14

Proteomic databases

Expression

Tissue specificity

Most abundant in embryos.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, zinc finger, domain.

TypeIDPosition(s)Description
Region30-53Disordered
Region119-139Disordered
Zinc finger151-171NR C4-type
Zinc finger187-211NR C4-type
Domain252-493NR LBD
Region502-534Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    534
  • Mass (Da)
    60,848
  • Last updated
    1996-10-01 v2
  • Checksum
    E6E888F18750E1B0
MSFETKPNYLLLTNPDTPLSVCTSPYYSPSGKTASIPSSEASKPEGTNGQWSHLPTGATYVTDEFSSEFQIQNGSTAAQSGNANNYADPLSHRRYFNNVNGYNHHQFYDTASQASVSSPATSVTSSLSPPDSLSNGHTTQRHHIGKAISFCKVCGDKASGYHYGVTSCEGCKGFFRRSIQRKIDYRCLKQQVCEIKRESRNRCQYCRFKKCLDSGMSKDSVRQMKFRNAMRDDKSPDSVFVPEISTLERQEEVDAVYEAVLRAHTTFSFYTDIKIRSIVARPFNVRINEDSKMNRLNAWQIYAHEIDVDIKEVVNFVKEIPKFNFINGNDKAVLLRKNAFPLYLLRIVRGMSNRGLMLRDGRLIDFKSLQLLYGSLADEMLAFANHIITIGCTDGDIALFIVLILCQPLTTEQQFSTNFKSQLQLLEMFDFYKKVLFQKMTCRIDGCDTYKQLMKCIHELNRLNELHKQQLNILRENLSFLNLPPLVVEMFQLSTLPLPVNHNNQENQYTPAPEHQSPQPQQPTPNQQQTPVHC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U13074
EMBL· GenBank· DDBJ
AAA96982.1
EMBL· GenBank· DDBJ
mRNA
BX284606
EMBL· GenBank· DDBJ
CAA90722.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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