This is the first study to suggest a role of VIPR2 in the genetic susceptibility to high myopia. EGR1 JUN FOS and VIP are unlikely to be important in predisposing humans to high myopia.
gene expression level and cAMP signaling of VIPR2 were increased in patients carrying 7q36.3 microduplications thus implicating VIPR2 in the etiology of schizophrenia.(review)
Results indicate that VPAC1 but not VPAC2 or PAC1 up-regulation in macrophages is a common mechanism in response to acute and chronic pro-inflammatory stimuli.
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