P41376 · IF4A1_ARATH
- ProteinEukaryotic initiation factor 4A-1
- GeneEIF4A1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids412 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic stress granule | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | translation initiation factor activity | |
Biological Process | cytoplasmic translational initiation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEukaryotic initiation factor 4A-1
- EC number
- Short nameseIF-4A-1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP41376
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000054949 | 2-412 | Eukaryotic initiation factor 4A-1 | |||
Sequence: AGSAPEGTQFDARQFDQKLNEVLEGQDEFFTSYDDVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDFSLIQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLKRQSLRADNIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTRDDERMLFDIQKFYNVVVEELPSNVADLL | ||||||
Modified residue | 104 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 145 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
PTM databases
Expression
Interaction
Subunit
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions (By similarity).
It is composed of at least EIF4A, EIF4E and EIF4G (By similarity).
Interacts with CDKA-1 (PubMed:14706832).
Interacts with MRF1, MRF2, MRF3/ECIP1 and MRF4 (PubMed:29084871).
It is composed of at least EIF4A, EIF4E and EIF4G (By similarity).
Interacts with CDKA-1 (PubMed:14706832).
Interacts with MRF1, MRF2, MRF3/ECIP1 and MRF4 (PubMed:29084871).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P41376 | CDKA-1 P24100 | 2 | EBI-371706, EBI-371713 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 39-67 | Q motif | ||||
Sequence: ESFDAMGLQENLLRGIYAYGFEKPSAIQQ | ||||||
Domain | 70-240 | Helicase ATP-binding | ||||
Sequence: IVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDFSLIQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLKRQSLRADNIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRI | ||||||
Motif | 188-191 | DEAD box | ||||
Sequence: DEAD | ||||||
Domain | 251-412 | Helicase C-terminal | ||||
Sequence: GIKQFYVNVEKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTRDDERMLFDIQKFYNVVVEELPSNVADLL |
Domain
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities
Belongs to the DEAD box helicase family. eIF4A subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
P41376-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length412
- Mass (Da)46,704
- Last updated1995-11-01 v1
- ChecksumE407BA7CBC967458
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A8MRZ7 | A8MRZ7_ARATH | EIF4A1 | 402 | ||
A0A1I9LSZ7 | A0A1I9LSZ7_ARATH | EIF4A1 | 419 | ||
F4JEL4 | F4JEL4_ARATH | EIF4A1 | 415 | ||
F4JEL5 | F4JEL5_ARATH | EIF4A1 | 407 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 91 | in Ref. 6; BAE98559 | ||||
Sequence: A → T | ||||||
Sequence conflict | 157 | in Ref. 6; BAE98559 | ||||
Sequence: G → S | ||||||
Sequence conflict | 249 | in Ref. 5; AAL91176 | ||||
Sequence: L → V |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X65052 EMBL· GenBank· DDBJ | CAA46188.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ298137 EMBL· GenBank· DDBJ | CAC43286.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AJ298138 EMBL· GenBank· DDBJ | CAC43288.1 EMBL· GenBank· DDBJ | mRNA | ||
AB019229 EMBL· GenBank· DDBJ | BAB02322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE75438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY050957 EMBL· GenBank· DDBJ | AAK93634.1 EMBL· GenBank· DDBJ | mRNA | ||
AY052344 EMBL· GenBank· DDBJ | AAK96536.1 EMBL· GenBank· DDBJ | mRNA | ||
AY081287 EMBL· GenBank· DDBJ | AAL91176.1 EMBL· GenBank· DDBJ | mRNA | ||
AY091304 EMBL· GenBank· DDBJ | AAM14243.1 EMBL· GenBank· DDBJ | mRNA | ||
AY098962 EMBL· GenBank· DDBJ | AAM19972.1 EMBL· GenBank· DDBJ | mRNA | ||
AY139981 EMBL· GenBank· DDBJ | AAM98124.1 EMBL· GenBank· DDBJ | mRNA | ||
BT000655 EMBL· GenBank· DDBJ | AAN31802.1 EMBL· GenBank· DDBJ | mRNA | ||
AK226414 EMBL· GenBank· DDBJ | BAE98559.1 EMBL· GenBank· DDBJ | mRNA | ||
AY086907 EMBL· GenBank· DDBJ | AAM63951.1 EMBL· GenBank· DDBJ | mRNA |