TNF-alpha Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis.
The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells.
WNT5A gene silencing reverses vincristine resistance in SKOV3/VCR cells possibly through blocking the PI3K/Akt/GSK3beta/beta-catenin signaling pathway and thus down-regulating the protein expression levels of MDR1 and Survivin.
results of study of WNT5A expression at the transcript and protein levels indicate that it could be considered as a potential marker of molecular changes that take place during EC development.
Results found that Wnt5a is overexpressed in glioma tumors. Also it is a direct target for ERR alpha. Wnt5a partly rescues the phenotypes caused by knockdown of ERRa in glioma cells.
Our results suggest that exosomal miR-92a-3p regulates cartilage development and homeostasis by directly targeting WNT5A. This indicates that exosomal miR-92a-3p may act as a Wnt inhibitor and exhibits potential as a disease-modifying osteoarthritis drug.
overexpression of Wnt5a in UM-UC-3 cells significantly increased cell viability while knock-down of Wnt5a by its siRNA in SW780 cells dramatically sensitized cells to gemcitabine. Our results identified Wnt5a as a target gene of miR-129-5p.
Results show that WNT5A induces castration resistance in prostate cancer (CRPC) cells and suggest that WNT5A may be a key gene that induces CRPC in the bone niche by recruiting and regulating macrophages through CCL2 and BMP6 respectively.
Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer which is involved in the activation of beta-catenin-dependent canonical Wnt signaling.
our study showed that for the first time different Wnt5a mRNA isoforms play distinct roles in colorectal cancer (CRC) and can be used as novel prognostic markers for CRC in the future.
The relationship between Wnt5a protein expression and histone H4K20me1 was analyzed. Recruitment of H4K20me1 and SET8 to the Wnt5a promoter and coding regions wa investigated. Results demonstrated that the expression levels of Wnt antagonists were generally low in acute myeloid leukemia (AML) but showed differential expression in acute lymphocytic leukemia (ALL).
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