P41121 · PNP_PHOLU

Function

function

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

1709100200300400500600700
TypeIDPosition(s)Description
Binding site486Mg2+ (UniProtKB | ChEBI)
Binding site492Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionpolyribonucleotide nucleotidyltransferase activity
Molecular FunctionRNA binding
Biological ProcessmRNA catabolic process
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyribonucleotide nucleotidyltransferase
  • EC number
  • Alternative names
    • Polynucleotide phosphorylase
      (PNPase
      )

Gene names

    • Name
      pnp
    • Synonyms
      pph

Organism names

Accessions

  • Primary accession
    P41121

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001979151-709Polyribonucleotide nucleotidyltransferase

Expression

Induction

In response to low temperature.

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain553-612KH
Domain622-690S1 motif

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    709
  • Mass (Da)
    76,745
  • Last updated
    1995-02-01 v1
  • Checksum
    EBFCC559FC921E6B
MLNPIVRKFQYGQHTVTIETGMMARQATAAVMVNMDDTAVFVTVVGQKKVKAGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPGEGETLVARLIDRPLRPLFPEGFLNEVRIVATVVSVNPQINPDIVAMIGASAALALSGIPFNGPIGAARVGYINDQYVLNPTSDELKNSRLDLVVSGTAGAVLMVESEADLLTEEQMLGAVVFGHDQQQVVIDNINALAAEAGKEKWDWVPEPVNQALHDRVAELAESRLGDAYRITEKQERYAQVDAIKDEVTAALLEQDETLEEAEIHEILGSLEKNVVRSRVLSGEPRIDGREKDMVRALDVRTGVLPRTHGSALFTRGETQALVTATLGTERDAQIIDELMGERTDRFLLHYNFPPYSVGETGMMGSPKRREIGHGRLAKRGVLAVMPKANEFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNFVVLSDILGDEDHLGDMDFKVAGSCEGISALQMDIKIEGITREIMQVALNQAKGARLHILSVMEQAITTPRDDISQFAPRIHTIKINPDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAISRIEEITAEIEVGRIYAGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVADYLQVGQETSVKVLEIDRQGRVRLSIKEATAGTAVEEAPPAPQSAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X76069
EMBL· GenBank· DDBJ
CAA53671.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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