P40941 · ADT2_ARATH

Function

function

ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).

Catalytic activity

Activity regulation

The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site157ADP (UniProtKB | ChEBI)
Binding site169ADP (UniProtKB | ChEBI)
Binding site315ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast envelope
Cellular Componentmitochondrial envelope
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Cellular Componentplant-type vacuole
Cellular Componentplastid
Molecular FunctionATP:ADP antiporter activity
Molecular Functioncopper ion binding
Biological Processmitochondrial ADP transmembrane transport
Biological Processmitochondrial ATP transmembrane transport
Biological Processpurine nucleotide transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ADP,ATP carrier protein 2, mitochondrial
  • Alternative names
    • ADP/ATP translocase 2
    • Adenine nucleotide translocator 2 (ANT 2)

Gene names

    • Name
      AAC2
    • Synonyms
      ANT2
    • ORF names
      T6I14_20
    • Ordered locus names
      At5g13490

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P40941
  • Secondary accessions
    • Q9FY52

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-111Helical; Name=1
Transmembrane152-176Helical; Name=2
Transmembrane185-205Helical; Name=3
Transmembrane256-277Helical; Name=4
Transmembrane291-311Helical; Name=5
Transmembrane351-371Helical; Name=6

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-74Mitochondrion
ChainPRO_000001924675-385ADP,ATP carrier protein 2, mitochondrial

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, region, motif.

Type
IDPosition(s)Description
Repeat82-175Solcar 1
Repeat187-280Solcar 2
Repeat288-374Solcar 3
Region315-320Important for transport activity
Motif315-320Nucleotide carrier signature motif

Domain

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    385
  • Mass (Da)
    41,746
  • Last updated
    2002-06-06 v2
  • Checksum
    87ADF762213207BA
MVEQTQHPTILQKVSGQLLSSSVSQDIRGYASASKRPATYQKHAAYGNYSNAAFQYPLVAASQIATTTSPVFVQAPGEKGFTNFAIDFMMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKAGRLTEPYKGIRDCFGRTIRDEGIGSLWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDKDGYWKWFAGNLASGGAAGASSLLFVYSLDYARTRLANDSKSAKKGGGERQFNGLVDVYKKTLKSDGIAGLYRGFNISCAGIIVYRGLYFGLYDSVKPVLLTGDLQDSFFASFALGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSFDAFSQIVKKEGAKSLFKGAGANILRAVAGAGVLAGYDKLQLIVFGKKYGSGGA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict228in Ref. 1; CAA48579

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X68592
EMBL· GenBank· DDBJ
CAA48579.1
EMBL· GenBank· DDBJ
mRNA
AL391710
EMBL· GenBank· DDBJ
CAC05426.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED91901.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED91902.1
EMBL· GenBank· DDBJ
Genomic DNA
AY050857
EMBL· GenBank· DDBJ
AAK92794.1
EMBL· GenBank· DDBJ
mRNA
AY079407
EMBL· GenBank· DDBJ
AAL85138.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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