P40941 · ADT2_ARATH
- ProteinADP,ATP carrier protein 2, mitochondrial
- GeneAAC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids385 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
Catalytic activity
- ADP(in) + ATP(out) = ADP(out) + ATP(in)This reaction proceeds in the forward direction.
Activity regulation
The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 157 | ADP (UniProtKB | ChEBI) | |||
Binding site | 169 | ADP (UniProtKB | ChEBI) | |||
Binding site | 315 | ADP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast envelope | |
Cellular Component | mitochondrial envelope | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Cellular Component | plant-type vacuole | |
Cellular Component | plastid | |
Molecular Function | ATP:ADP antiporter activity | |
Molecular Function | copper ion binding | |
Biological Process | mitochondrial ADP transmembrane transport | |
Biological Process | mitochondrial ATP transmembrane transport | |
Biological Process | purine nucleotide transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameADP,ATP carrier protein 2, mitochondrial
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP40941
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 84-111 | Helical; Name=1 | |||
Transmembrane | 152-176 | Helical; Name=2 | |||
Transmembrane | 185-205 | Helical; Name=3 | |||
Transmembrane | 256-277 | Helical; Name=4 | |||
Transmembrane | 291-311 | Helical; Name=5 | |||
Transmembrane | 351-371 | Helical; Name=6 | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-74 | Mitochondrion | |||
Chain | PRO_0000019246 | 75-385 | ADP,ATP carrier protein 2, mitochondrial | ||
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat, region, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 82-175 | Solcar 1 | |||
Repeat | 187-280 | Solcar 2 | |||
Repeat | 288-374 | Solcar 3 | |||
Region | 315-320 | Important for transport activity | |||
Motif | 315-320 | Nucleotide carrier signature motif | |||
Domain
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length385
- Mass (Da)41,746
- Last updated2002-06-06 v2
- Checksum87ADF762213207BA
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 228 | in Ref. 1; CAA48579 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X68592 EMBL· GenBank· DDBJ | CAA48579.1 EMBL· GenBank· DDBJ | mRNA | ||
AL391710 EMBL· GenBank· DDBJ | CAC05426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED91901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED91902.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY050857 EMBL· GenBank· DDBJ | AAK92794.1 EMBL· GenBank· DDBJ | mRNA | ||
AY079407 EMBL· GenBank· DDBJ | AAL85138.1 EMBL· GenBank· DDBJ | mRNA |