P40830 · PKSG_BACSU

  • Protein
    Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
  • Gene
    pksG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac-AcpK) and a beta-ketothioester polyketide intermediate linked to one of the consecutive thiolation domains of PksL.

Pathway

Antibiotic biosynthesis; bacillaene biosynthesis.

Features

Showing features for active site.

142050100150200250300350400
TypeIDPosition(s)Description
Active site82Proton donor/acceptor
Active site114Acyl-thioester intermediate
Active site250Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhydroxymethylglutaryl-CoA synthase activity
Biological Processacetyl-CoA metabolic process
Biological Processantibiotic biosynthetic process
Biological Processfarnesyl diphosphate biosynthetic process, mevalonate pathway

Keywords

Enzyme and pathway databases

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
  • EC number
  • Short names
    HMG synthase

Gene names

    • Name
      pksG
    • Ordered locus names
      BSU17150

Organism names

Accessions

  • Primary accession
    P40830

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002137591-420Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    46,780
  • Last updated
    2004-03-29 v2
  • Checksum
    8808BDDFEEAC8F70
MVSAGIEAMNVFGGTAYLDVMELAKYRHLDTARFENLLMKEKAVALPYEDPVTFGVNAAKPIIDALSEAEKDRIELLITCSESGIDFGKSLSTYIHEYLGLNRNCRLFEVKQACYSGTAGFQMAVNFILSQTSPGAKALVIASDISRFLIAEGGDALSEDWSYAEPSAGAGAVAVLVGENPEVFQIDPGANGYYGYEVMDTCRPIPDSEAGDSDLSLMSYLDCCEQTFLEYQKRVPGANYQDTFQYLAYHTPFGGMVKGAHRTMMRKVAKVKTSGIETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRFDTPKRIGCFSYGSGCCSEFYSGITTPQGQERQRTFGIEKHLDRRYQLSMEEYELLFKGSGMVRFGTRNVKLDFEMIPGIMQSTQEKPRLFLEEISEFHRKYRWIS

Sequence caution

The sequence AAA85140.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U11039
EMBL· GenBank· DDBJ
AAA85140.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AL009126
EMBL· GenBank· DDBJ
CAB13586.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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