P40807 · DCOR1_DROME
- ProteinOrnithine decarboxylase 1
- GeneOdc1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids394 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Catalytic activity
- L-ornithine + H+ = putrescine + CO2
Cofactor
Activity regulation
Inhibited by antizyme (AZ) in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.
Pathway
Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 191 | Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates | |||
Binding site | 194 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 231 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 265-268 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 314-315 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 343 | Proton donor; shared with dimeric partner | |||
Binding site | 344 | substrate; ligand shared between dimeric partners | |||
Binding site | 372 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ornithine decarboxylase activity | |
Biological Process | putrescine biosynthetic process from ornithine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrnithine decarboxylase 1
- EC number
- Short namesODC
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP40807
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000149899 | 1-394 | Ornithine decarboxylase 1 | ||
Modified residue | 62 | N6-(pyridoxal phosphate)lysine | |||
Proteomic databases
Expression
Structure
Sequence
- Sequence statusComplete
- Length394
- Mass (Da)44,195
- Last updated2005-04-12 v3
- Checksum5D2F348D1467E39B
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 44-45 | in Ref. 1; CAA47167/CAA47165 | |||
Sequence conflict | 242 | in Ref. 1; CAA47165 | |||
Sequence conflict | 325 | in Ref. 1; CAA47165 | |||
Sequence conflict | 348 | in Ref. 1; CAA47165 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X66601 EMBL· GenBank· DDBJ | CAA47167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X66599 EMBL· GenBank· DDBJ | CAA47165.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF59150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY094710 EMBL· GenBank· DDBJ | AAM11063.1 EMBL· GenBank· DDBJ | mRNA |