P40807 · DCOR1_DROME

Function

function

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Activity regulation

Inhibited by antizyme (AZ) in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site191Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates
Binding site194pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site231pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site265-268pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site314-315substrate; ligand shared between dimeric partners; in other chain
Active site343Proton donor; shared with dimeric partner
Binding site344substrate; ligand shared between dimeric partners
Binding site372pyridoxal 5'-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionornithine decarboxylase activity
Biological Processputrescine biosynthetic process from ornithine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ornithine decarboxylase 1
  • EC number
  • Short names
    ODC

Gene names

    • Name
      Odc1
    • ORF names
      CG8721

Organism names

  • Taxonomic identifier
  • Strains
    • Canton-S
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P40807
  • Secondary accessions
    • Q9V352

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001498991-394Ornithine decarboxylase 1
Modified residue62N6-(pyridoxal phosphate)lysine

Proteomic databases

Expression

Developmental stage

Expressed in adults.

Gene expression databases

    • FBgn0013307Expressed in head capsule and 18 other cell types or tissues

Interaction

Subunit

Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    394
  • Mass (Da)
    44,195
  • Last updated
    2005-04-12 v3
  • Checksum
    5D2F348D1467E39B
MAAATPEIQFYERELNIRRVIEECDLQRLDQALNICDLSSVERKLRLWQKLLPRIKPFYAVKCNDDPMVVRLLAQLGAGFDCASKNEVKLVLGFDVSPERIIFANPCRPVSHLEYAKEHQVSNGTVDNEFEVYKLHTHYPNSNLIVRFKSEAKEAQCPLGDKFGCDADVDAAALMLLAKSLELKVTGTSFHVGSGCSELQAYDRAIKKAKNLFKFGALLGYDMDFLDIGGGFPGSDDVKFEKIAESVNTSVQRHFPDERVHIIAEPGRFFVAAACTLVCKIHAKREIRNEAGKLDTVMYYLNDGVYGSFNCILYDHQVVIAEHYLDNAESLPHLKSLIWGPSCDALDKISEDLHLPNLNRGDLLGFRNMGAYTMPIASAFNGFEVPKTLYFQAI

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict44-45in Ref. 1; CAA47167/CAA47165
Sequence conflict242in Ref. 1; CAA47165
Sequence conflict325in Ref. 1; CAA47165
Sequence conflict348in Ref. 1; CAA47165

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X66601
EMBL· GenBank· DDBJ
CAA47167.1
EMBL· GenBank· DDBJ
Genomic DNA
X66599
EMBL· GenBank· DDBJ
CAA47165.1
EMBL· GenBank· DDBJ
mRNA
AE013599
EMBL· GenBank· DDBJ
AAF59150.1
EMBL· GenBank· DDBJ
Genomic DNA
AY094710
EMBL· GenBank· DDBJ
AAM11063.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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