P40797 · PNUT_DROME

Function

function

Involved in cytokinesis and possibly cellularization (PubMed:8181057).
Also acts as an enhancer of the sina gene, thus having a role in photoreceptor development (PubMed:8181057).
May be involved in p53-dependent apoptosis (PubMed:17456438).

Features

Showing features for binding site.

153950100150200250300350400450500
TypeIDPosition(s)Description
Binding site149-156GTP (UniProtKB | ChEBI)
Binding site183GTP (UniProtKB | ChEBI)
Binding site209GTP (UniProtKB | ChEBI)
Binding site288-296GTP (UniProtKB | ChEBI)
Binding site345GTP (UniProtKB | ChEBI)
Binding site360GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell division site
Cellular Componentcleavage furrow
Cellular Componentcontractile ring
Cellular Componentintercellular bridge
Cellular Componentmicrotubule cytoskeleton
Cellular Componentmitochondrion
Cellular Componentplasma membrane
Cellular Componentseptin complex
Cellular Componentseptin ring
Molecular Functionactin binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmicrotubule binding
Molecular Functionmolecular adaptor activity
Molecular Functionprotein homodimerization activity
Molecular Functionubiquitin protein ligase binding
Biological Processapoptotic process
Biological Processcellularization
Biological Processcilium assembly
Biological Processcytoskeleton-dependent cytokinesis
Biological Processimaginal disc-derived wing morphogenesis
Biological Processmitotic cytokinesis
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of imaginal disc growth
Biological Processprotein localization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein peanut

Gene names

    • Name
      pnut
    • ORF names
      CG8705

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P40797
  • Secondary accessions
    • Q0E9F5
    • Q9V385

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Peripheral membrane protein
Cleavage furrow
Note: Localized to the cleavage furrow of dividing cells during cytokinesis and to the intercellular bridge connecting postmitotic daughter cells. Equally found on the cell surfaces of the embryonic central nervous system and on the apical membranes of developing photoreceptor cells in the eye imaginal disk (PubMed:8181057).
Colocalizes with hil at the cell cortex (PubMed:15818553).

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001735101-539Protein peanut
Modified residue6Phosphoserine
Modified residue13Phosphoserine
Modified residue517Phosphoserine

Post-translational modification

Ubiquitinated by park, leading to its degradation by the proteasome.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Accumulates at the leading edge of the cleavage furrow in dividing cells and cellularizing embryos (at protein level).

Developmental stage

Maternal gene products found in the early embryo prior to zygotic transcription.

Gene expression databases

Interaction

Subunit

Likely part of a multicomponent septin complex that includes Septin1 (PubMed:8590810).
Interacts with Septin1 (PubMed:8590810).
Interacts with hil (PubMed:15818553).
Interacts with park (PubMed:17456438).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain, coiled coil.

TypeIDPosition(s)Description
Compositional bias29-52Polar residues
Region29-90Disordered
Domain139-411Septin-type G
Region149-156G1 motif
Region206-209G3 motif
Region287-290G4 motif
Coiled coil420-516
Region513-539Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    539
  • Mass (Da)
    60,143
  • Last updated
    2005-11-08 v2
  • Checksum
    A8009F7E6F331A32
MNSPRSNAVNGGSGGAISALPSTLAQLALRDKQQAASASASSATNGSSGSESLVGVGGRPPNQPPSVPVAASGKLDTSGGGASNGDSNKLTHDLQEKEHQQAQKPQKPPLPVRQKPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYRKTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNKNPLTQMEEEKREHEQKMKKMEAEMEQVFDMKVKEKMQKLRDSELELARRHEERKKALELQIRELEEKRREFEREKKEWEDVNHVTLEELKRRSLGANSSTDNVDGKKEKKKKGLF

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias29-52Polar residues
Sequence conflict79in Ref. 1; AAA19603
Sequence conflict249in Ref. 1; AAA19603

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U08103
EMBL· GenBank· DDBJ
AAA19603.1
EMBL· GenBank· DDBJ
mRNA
AE013599
EMBL· GenBank· DDBJ
AAM68857.1
EMBL· GenBank· DDBJ
Genomic DNA
AY058663
EMBL· GenBank· DDBJ
AAL13892.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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