P40633 · TBG_COCH5

Function

function

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).

Features

Showing features for binding site.

145950100150200250300350400450
TypeIDPosition(s)Description
Binding site142-148GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentgamma-tubulin complex
Cellular Componentmicrotubule
Cellular Componentnucleus
Cellular Componentspindle
Cellular Componentspindle pole body
Molecular FunctionGTP binding
Molecular Functionstructural constituent of cytoskeleton
Biological Processcytoplasmic microtubule organization
Biological Processmeiotic spindle organization
Biological Processmicrotubule nucleation
Biological Processmitotic sister chromatid segregation
Biological Processmitotic spindle organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tubulin gamma chain
  • Alternative names
    • Gamma-tubulin

Gene names

    • Name
      TUB4
    • ORF names
      COCHEDRAFT_1179534

Organism names

Accessions

  • Primary accession
    P40633
  • Secondary accessions
    • M2SYV7

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000484521-459Tubulin gamma chain

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region440-459Disordered
Compositional bias441-459Basic and acidic residues

Sequence similarities

Belongs to the tubulin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    51,489
  • Last updated
    2013-09-18 v3
  • Checksum
    EC25A2DAC8423199
MPREIITLQAGQCGNSVGQQFWQQLCQEHGINKDGNLEDFATEGGDRKDVFFYQSDDTRYIPRAILLDLEPRVLHSIQASPYKNIYNPENFYIHKDGTGAGNNWGMGYSMGEQVHEDILDMIDREADGSDSLEGFMMLHSIAGGTGSGLGSYMLERLNDRFPKKLIQTYSVFPNTQDGDIVVQPYNSLLSMRRLTQNADSVVVLDNGALTRIAADRLHVMNPSFEQTNQLVSTVMSASTTTLRYPGYMHNDLVGIVASLIPTPRCHFLMTSYTPFSGENVEQAKTVRKTTVLDVMRRLLQPKNRMVSTNPTKKSCYMSILNIIQGEADPSDVHKSLMRIRERRLATFIPWGPASIQVALTKKSPYVTSSHRVSGLMLANHTGIATLFKRIVAQYSTLRKRNAFLESYKREVPFKDGLGEFDEAKEVVQGLIAEYEEAEDADYLTKETAPTDEAEDKRAG

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict67in Ref. 3; CAA52464
Sequence conflict119in Ref. 3; CAA52464
Sequence conflict221in Ref. 3; CAA52464
Sequence conflict246-248in Ref. 3; CAA52464
Sequence conflict274in Ref. 3; CAA52464
Sequence conflict312in Ref. 3; CAA52464
Sequence conflict325-330in Ref. 3; CAA52464
Compositional bias441-459Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB445578
EMBL· GenBank· DDBJ
EMD90570.1
EMBL· GenBank· DDBJ
Genomic DNA
X74455
EMBL· GenBank· DDBJ
CAA52464.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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