P40475 · QDR1_YEAST
- ProteinQuinidine resistance protein 1
- GeneQDR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids563 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | plasma membrane | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | transmembrane transporter activity | |
Biological Process | ascospore wall assembly | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameQuinidine resistance protein 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP40475
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-75 | Cytoplasmic | ||||
Sequence: MTKQQTSVMRNASIAKEEREGSDNNNVDRSSSDAISDNDAERSNSHSEIDNESNFDMVPYSRFSHKQKMLLVVQC | ||||||
Transmembrane | 76-96 | Helical | ||||
Sequence: AFTGFFSTVAGSIYYPVLTII | ||||||
Topological domain | 97-108 | Extracellular | ||||
Sequence: ERKFNITEELAN | ||||||
Transmembrane | 109-129 | Helical | ||||
Sequence: VTIVVYFIFQGVAPSIMGGLA | ||||||
Topological domain | 130-135 | Cytoplasmic | ||||
Sequence: DTFGRR | ||||||
Transmembrane | 136-156 | Helical | ||||
Sequence: PIVLWAILAYFCACIGLACAH | ||||||
Topological domain | 157-165 | Extracellular | ||||
Sequence: NYAQILALR | ||||||
Transmembrane | 166-186 | Helical | ||||
Sequence: CLQAAGISPVIAINSGIMGDV | ||||||
Topological domain | 187-195 | Cytoplasmic | ||||
Sequence: TTKVERGGY | ||||||
Transmembrane | 196-216 | Helical | ||||
Sequence: VGLVAGFQVVGTAFGALIGAG | ||||||
Topological domain | 217-224 | Extracellular | ||||
Sequence: LSSKWGWR | ||||||
Transmembrane | 225-245 | Helical | ||||
Sequence: AIFWFLAIGSGICLVFSTLLM | ||||||
Topological domain | 246-296 | Cytoplasmic | ||||
Sequence: PETKRTLVGNGSVTPRSFLNRSLILHVGSVKKTLHLDDPDPETLEPRTSVD | ||||||
Transmembrane | 297-317 | Helical | ||||
Sequence: FLAPLKILHIREIDILLSIAG | ||||||
Topological domain | 318-341 | Extracellular | ||||
Sequence: LQFSTWTTHQTALTIVLSKKYNLS | ||||||
Transmembrane | 342-362 | Helical | ||||
Sequence: VAKIGLCFLPAGISTLTSIIS | ||||||
Topological domain | 363-421 | Cytoplasmic | ||||
Sequence: AGRYLNWSYRTRKVKYNRWIKEQELQLMEKYKGDKNKVAELIHSNSHYAFNLVEARLHP | ||||||
Transmembrane | 422-442 | Helical | ||||
Sequence: AFVTLLLSSIGFTAFGWCISV | ||||||
Topological domain | 443-445 | Extracellular | ||||
Sequence: KTP | ||||||
Transmembrane | 446-466 | Helical | ||||
Sequence: LAAVLCTSAFASLFSNCILTF | ||||||
Topological domain | 467-481 | Cytoplasmic | ||||
Sequence: STTLIVDLFPSKAST | ||||||
Transmembrane | 482-502 | Helical | ||||
Sequence: ATGCLNLFRCLLSAIFIAALT | ||||||
Topological domain | 503-511 | Extracellular | ||||
Sequence: KMVEKMRYG | ||||||
Transmembrane | 512-532 | Helical | ||||
Sequence: GVFTFLSAITSSSSLLLFYLL | ||||||
Topological domain | 533-563 | Cytoplasmic | ||||
Sequence: KNGKQLSFDRIRANDKSAGRSVGKNSEKVST |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000173441 | 1-563 | Quinidine resistance protein 1 | |||
Sequence: MTKQQTSVMRNASIAKEEREGSDNNNVDRSSSDAISDNDAERSNSHSEIDNESNFDMVPYSRFSHKQKMLLVVQCAFTGFFSTVAGSIYYPVLTIIERKFNITEELANVTIVVYFIFQGVAPSIMGGLADTFGRRPIVLWAILAYFCACIGLACAHNYAQILALRCLQAAGISPVIAINSGIMGDVTTKVERGGYVGLVAGFQVVGTAFGALIGAGLSSKWGWRAIFWFLAIGSGICLVFSTLLMPETKRTLVGNGSVTPRSFLNRSLILHVGSVKKTLHLDDPDPETLEPRTSVDFLAPLKILHIREIDILLSIAGLQFSTWTTHQTALTIVLSKKYNLSVAKIGLCFLPAGISTLTSIISAGRYLNWSYRTRKVKYNRWIKEQELQLMEKYKGDKNKVAELIHSNSHYAFNLVEARLHPAFVTLLLSSIGFTAFGWCISVKTPLAAVLCTSAFASLFSNCILTFSTTLIVDLFPSKASTATGCLNLFRCLLSAIFIAALTKMVEKMRYGGVFTFLSAITSSSSLLLFYLLKNGKQLSFDRIRANDKSAGRSVGKNSEKVST |
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-50 | Disordered | ||||
Sequence: MTKQQTSVMRNASIAKEEREGSDNNNVDRSSSDAISDNDAERSNSHSEID | ||||||
Compositional bias | 34-49 | Basic and acidic residues | ||||
Sequence: AISDNDAERSNSHSEI |
Sequence similarities
Belongs to the major facilitator superfamily. CAR1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length563
- Mass (Da)61,759
- Last updated1995-02-01 v1
- Checksum5FDBA6F9F7C71C72
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-49 | Basic and acidic residues | ||||
Sequence: AISDNDAERSNSHSEI |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z46833 EMBL· GenBank· DDBJ | CAA86872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006942 EMBL· GenBank· DDBJ | DAA08433.1 EMBL· GenBank· DDBJ | Genomic DNA |