Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.de Sauvage F.J., Hass P.E., Spencer S.D., Malloy B.E., Gurney A.L., Spencer S.A., Darbonne W.C., Henzel W.J., Wong S.C.[...], Eaton D.L.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)TissueFetal liverCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 369:533-538 (1994)Cited in2Mapped to1
Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.Bartley T.D., Bogenberger J., Hunt P., Li Y.-S., Lu H.S., Martin F., Chang M.-S., Samal B.B., Nichol J.L.[...], Bosselman R.A.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)TissueFetal liverCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 77:1117-1124 (1994)Cited in3
Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.Foster D.C., Sprecher C.A., Grant F.J., Kramer J.M., Kuijper J.L., Holly R.D., Whitmore T.E., Heipel M.D., Bell L.A.N.[...], Lok S.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 91:13023-13027 (1994)Cited in1
Molecular cloning and chromosomal localization of the human thrombopoietin gene.Sohma Y., Akahori H., Seki N., Hori T.-A., Ogami K., Kawamura K., Miyazaki H.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFEBS Lett. 353:57-61 (1994)Cited in1
Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin.Gurney A.L., Kuang W.-J., Xie M.-H., Malloy B.E., Eaton D.L., de Sauvage F.J.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 85:981-988 (1995)Cited in2Mapped to3
Purification and characterization of thrombopoietin.Kato T., Ogami K., Shimada Y., Iwamatsu A., Sohma Y., Akahori H., Horie K., Kokubo A., Kudo Y.[...], Miyazaki H.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)TissueLiverCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biochem. 118:229-236 (1995)Cited in1
Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene.Chang M., McNinch J., Basu R., Shutter J., Hsu R., Perkins C., Mar V., Suggs S., Welcher A.[...], Bogenberger J.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), SUBCELLULAR LOCATIONTissuePlacentaCategoriesSequences, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 270:511-514 (1995)Cited in1
Cloning and sequencing of human thrombopoietin.Im S.H., Lee W.S., Chung K.H.Cited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (MAY-1996)Cited in1
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)TissueBrain, TestisCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.Wiestner A., Schlemper R.J., van der Maas A.P.C., Skoda R.C.View abstractCited forINVOLVEMENT IN THCYT1CategoriesDisease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Genet. 18:49-52 (1998)Cited in1
Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.Hoffman R.C., Andersen H., Walker K., Krakover J.D., Patel S., Stamm M.R., Osborn S.G.View abstractCited forDISULFIDE BONDS, GLYCOSYLATION AT SER-22; THR-58; THR-131; THR-179; THR-180; SER-184; ASN-197; ASN-206; THR-213; ASN-234; ASN-255 AND SER-265CategoriesPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochemistry 35:14849-14861 (1996)Cited in1
Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia.Dasouki M.J., Rafi S.K., Olm-Shipman A.J., Wilson N.R., Abhyankar S., Ganter B., Furness L.M., Fang J., Calado R.T., Saadi I.View abstractCited forFUNCTION, INVOLVEMENT IN CAMT2, VARIANT CAMT2 CYS-38CategoriesFunction, Sequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 122:3440-3449 (2013)Cited in1
A new form of inherited thrombocytopenia due to monoallelic loss of function mutation in the thrombopoietin gene.Noris P., Marconi C., De Rocco D., Melazzini F., Pippucci T., Loffredo G., Giangregorio T., Pecci A., Seri M., Savoia A.Cited forINVOLVEMENT IN THC9, VARIANT THC9 31-ARG--GLY-353 DELCategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBr. J. Haematol. 181:698-701 (2018)Cited in1
Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostim.Pecci A., Ragab I., Bozzi V., De Rocco D., Barozzi S., Giangregorio T., Ali H., Melazzini F., Sallam M.[...], Savoia A.View abstractCited forFUNCTION, VARIANT CAMT2 CYS-119, CHARACTERIZATION OF VARIANTS CAMT2 CYS-38 AND CYS-119CategoriesFunction, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO Mol. Med. 10:63-75 (2018)Cited in1
Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.Capaci V., Adam E., Bar-Joseph I., Faleschini M., Pecci A., Savoia A.View abstractCited forINVOLVEMENT IN CAMT2CategoriesDisease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCHaematologica 108:1385-1393 (2023)Cited in1Mapped to15
Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment.Feese M.D., Tamada T., Kato Y., Maeda Y., Hirose M., Matsukura Y., Shigematsu H., Muto T., Matsumoto A.[...], Kuroki R.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 22-184 IN COMPLEX WITH ANTIBODY, DISULFIDE BONDSCategoriesPTM / Processing, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 101:1816-1821 (2004)Cited in1
Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin.Seo A., Ben-Harosh M., Sirin M., Stein J., Dgany O., Kaplelushnik J., Hoenig M., Pannicke U., Lorenz M.[...], Shimamura A.View abstractCited forVARIANTS CAMT2 TRP-99 AND 157-ARG--GLY-353 DELCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 130:875-880 (2017)Cited in1
Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia.NIHR BioResourceCornish N., Aungraheeta M.R., FitzGibbon L., Burley K., Alibhai D., Collins J., Greene D., Downes K., Westbury S.K.[...], Mumford A.D.Cited forVARIANT THC9 TRP-99, CHARACTERIZATION OF VARIANT THC9 TRP-99, SUBCELLULAR LOCATIONCategoriesSequences, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood Adv. 4:920-924 (2020)Cited in1
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.Tsutsumi N., Masoumi Z., James S.C., Tucker J.A., Winkelmann H., Grey W., Picton L.K., Moss L., Wilson S.C.[...], Garcia K.C.View abstractCategoriesStructureSourcePDB: 8G04PubMedEurope PMCCell 186:4189-4203.e22 (2023)Mapped to11
Toward an understanding of the protein interaction network of the human liver.Wang J., Huo K., Ma L., Tang L., Li D., Huang X., Yuan Y., Li C., Wang W.[...], Yang X.View abstractCategoriesInteractionSourceIntAct: P40225PubMedEurope PMCMol Syst Biol 7:536-536 (2011)Mapped to99+
Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors.Hirashiki A., Yamada Y., Murase Y., Suzuki Y., Kataoka H., Morimoto Y., Tajika T., Murohara T., Yokota M.View abstractAnnotationNot Associated with CARDIOVASCULAR: coronary artery disease.CategoriesDisease & VariantsSourceGAD:136243PubMedEurope PMCJ Am Coll Cardiol 42:1429-1437 (2003)Mapped to99+
Crystallization of the functional domain of human thrombopoietin using an antigen-binding fragment derived from neutralizing monoclonal antibody.Kuroki R., Hirose M., Kato Y., Feese M.D., Tamada T., Shigematsu H., Watarai H., Maeda Y., Tahara T.[...], Miyazaki H.View abstractCategoriesStructureSourcePDB: 1V7M, PDB: 1V7NPubMedEurope PMCActa Crystallogr D Biol Crystallogr 58:856-858 (2002)Mapped to1
Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia.Allen A.J., Gale R.E., Harrison C.N., Machin S.J., Linch D.C.View abstractAnnotationNot Associated with HEMATOLOGICAL: thrombocythemia, non-familial essential.CategoriesDisease & VariantsSourceGAD:136245PubMedEurope PMCEur J Haematol 67:232-237 (2001)Mapped to9
Polymorphisms in the thrombopoietin gene are associated with risk of myocardial infarction at a young age.Webb K.E., Martin J.F., Hamsten A., Eriksson P., Iacoviello L., Gattone M., Donati M.B., Di Castelnuovo A., Erusalimsky J., Humphries S.E.View abstractAnnotationAssociated with CARDIOVASCULAR: myocardial infarction.CategoriesDisease & VariantsSourceGAD:136242, GAD:136244PubMedEurope PMCAtherosclerosis 154:703-711 (2001)Mapped to9