P40073 · SHO1_YEAST

Function

function

Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway.

Miscellaneous

Present with 2330 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell periphery
Cellular Componentcellular bud
Cellular Componentcellular bud neck
Cellular Componentendoplasmic reticulum
Cellular ComponentHICS complex
Cellular Componentmating projection tip
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular FunctionMAP-kinase scaffold activity
Molecular Functionosmosensor activity
Biological Processestablishment of cell polarity
Biological Processmitotic cytokinetic process
Biological Processosmosensory signaling pathway
Biological Processosmosensory signaling pathway via Sho1 osmosensor
Biological Processregulation of actin filament polymerization
Biological Processsignal transduction involved in filamentous growth

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    High osmolarity signaling protein SHO1
  • Alternative names
    • Osmosensor SHO1
    • Suppressor of SUA8-1 mutation
    • Synthetic high osmolarity-sensitive protein 1

Gene names

    • Name
      SHO1
    • Synonyms
      SSU81
    • Ordered locus names
      YER118C

Organism names

Accessions

  • Primary accession
    P40073
  • Secondary accessions
    • D3DM24

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-32Cytoplasmic
Transmembrane33-53Helical
Topological domain54-65Extracellular
Transmembrane66-86Helical
Topological domain87-93Cytoplasmic
Transmembrane94-114Helical
Topological domain115-122Extracellular
Transmembrane123-143Helical
Topological domain144-367Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis166Diminishes the formation of oligomers, dampens activation of the HOG1 kinase, and impairs growth in high-salt or sorbitol conditions.
Mutagenesis309Decreases the interaction with PBS2 and leads to decreased HOG pathway response and increased aberrant mating pathway activation.
Mutagenesis317Decreases the interaction with PBS2 and leads to decreased HOG pathway response and increased aberrant mating pathway activation.
Mutagenesis355Decreases the interaction with PBS2 and leads to decreased HOG pathway response and increased aberrant mating pathway activation.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 9 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000722311-367High osmolarity signaling protein SHO1
Glycosylation59N-linked (GlcNAc...) asparagine
Modified residue166Phosphoserine

Keywords

Proteomic databases

PTM databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region252-276Disordered
Domain300-361SH3

Sequence similarities

Belongs to the SHO1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    41,126
  • Last updated
    1995-02-01 v1
  • Checksum
    E467A4D50AA3EDB6
MSISSKIRPTPRKPSRMATDHSFKMKKFYADPFAISSISLAIVSWVIAIGGSISSASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNLVYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHRARRRGNRNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTALAGFENTQPNTSEAVNLHLNTLQQRINSASNAKETNDNSNNQTNTNIGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFIYKAKALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMHR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U15653
EMBL· GenBank· DDBJ
AAA61904.1
EMBL· GenBank· DDBJ
Genomic DNA
L41926
EMBL· GenBank· DDBJ
AAC41664.1
EMBL· GenBank· DDBJ
Genomic DNA
U18916
EMBL· GenBank· DDBJ
AAC03216.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006939
EMBL· GenBank· DDBJ
DAA07778.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp