P39966 · PP2C2_YEAST

Function

function

Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.

Miscellaneous

Present with 12600 molecules/cell in log phase SD medium.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium or manganese ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site62Mn2+ 1 (UniProtKB | ChEBI)
Binding site62Mn2+ 2 (UniProtKB | ChEBI)
Binding site63Mn2+ 1 (UniProtKB | ChEBI)
Binding site234Mn2+ 2 (UniProtKB | ChEBI)
Binding site283Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionMAP kinase serine/threonine phosphatase activity
Molecular Functionmetal ion binding
Molecular Functionmyosin phosphatase activity
Molecular Functionprotein serine/threonine phosphatase activity
Biological Processnegative regulation of endoplasmic reticulum unfolded protein response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein phosphatase 2C homolog 2
  • EC number
  • Short names
    PP2C-2

Gene names

    • Name
      PTC2
    • Ordered locus names
      YER089C

Organism names

Accessions

  • Primary accession
    P39966
  • Secondary accessions
    • D3DLZ6

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000577751-464Protein phosphatase 2C homolog 2
Modified residue376Phosphothreonine
Modified residue380Phosphothreonine

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P39966PAA1 Q124479EBI-12795, EBI-33397

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain23-292PPM-type phosphatase
Region361-398Disordered
Compositional bias368-382Acidic residues
Compositional bias383-398Polar residues
Region434-464Disordered
Compositional bias448-464Basic and acidic residues

Sequence similarities

Belongs to the PP2C family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    50,388
  • Last updated
    1995-02-01 v1
  • Checksum
    61D82D2CA4ED3FED
MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALLKEGEDVAQWSDRMKSKAHRTSVRSFADKRRRVFSYYDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGPIDLASLEALLGATGGVKTDSNGNKVTYTLPQSALAQLLQTMGHDPASSHPENDSNTDHKAGRSHLQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias368-382Acidic residues
Compositional bias383-398Polar residues
Compositional bias448-464Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U18839
EMBL· GenBank· DDBJ
AAB64644.1
EMBL· GenBank· DDBJ
Genomic DNA
U72498
EMBL· GenBank· DDBJ
AAB17392.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006939
EMBL· GenBank· DDBJ
DAA07750.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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