P39966 · PP2C2_YEAST
- ProteinProtein phosphatase 2C homolog 2
- GenePTC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids464 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.
Miscellaneous
Present with 12600 molecules/cell in log phase SD medium.
Catalytic activity
- H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium or manganese ions per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | MAP kinase serine/threonine phosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | protein serine/threonine phosphatase activity | |
Biological Process | negative regulation of endoplasmic reticulum unfolded protein response |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein phosphatase 2C homolog 2
- EC number
- Short namesPP2C-2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP39966
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000057775 | 1-464 | Protein phosphatase 2C homolog 2 | |||
Sequence: MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALLKEGEDVAQWSDRMKSKAHRTSVRSFADKRRRVFSYYDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGPIDLASLEALLGATGGVKTDSNGNKVTYTLPQSALAQLLQTMGHDPASSHPENDSNTDHKAGRSHLQ | ||||||
Modified residue | 376 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 380 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P39966 | PAA1 Q12447 | 9 | EBI-12795, EBI-33397 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-292 | PPM-type phosphatase | ||||
Sequence: AFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVAL | ||||||
Region | 361-398 | Disordered | ||||
Sequence: SVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGP | ||||||
Compositional bias | 368-382 | Acidic residues | ||||
Sequence: DDPMDIDDTDADTDA | ||||||
Compositional bias | 383-398 | Polar residues | ||||
Sequence: ENLDPSSQSKSKTSGP | ||||||
Region | 434-464 | Disordered | ||||
Sequence: QLLQTMGHDPASSHPENDSNTDHKAGRSHLQ | ||||||
Compositional bias | 448-464 | Basic and acidic residues | ||||
Sequence: PENDSNTDHKAGRSHLQ |
Sequence similarities
Belongs to the PP2C family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)50,388
- Last updated1995-02-01 v1
- Checksum61D82D2CA4ED3FED
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 368-382 | Acidic residues | ||||
Sequence: DDPMDIDDTDADTDA | ||||||
Compositional bias | 383-398 | Polar residues | ||||
Sequence: ENLDPSSQSKSKTSGP | ||||||
Compositional bias | 448-464 | Basic and acidic residues | ||||
Sequence: PENDSNTDHKAGRSHLQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U18839 EMBL· GenBank· DDBJ | AAB64644.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U72498 EMBL· GenBank· DDBJ | AAB17392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006939 EMBL· GenBank· DDBJ | DAA07750.1 EMBL· GenBank· DDBJ | Genomic DNA |