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P39954 · SAHH_YEAST

Function

function

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )
Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site58substrate
Binding site134substrate
Binding site159substrate
Binding site160-162NAD+ (UniProtKB | ChEBI)
Binding site189substrate
Binding site193substrate
Binding site194NAD+ (UniProtKB | ChEBI)
Binding site223-228NAD+ (UniProtKB | ChEBI)
Binding site246NAD+ (UniProtKB | ChEBI)
Binding site302-304NAD+ (UniProtKB | ChEBI)
Binding site349NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Molecular Functionadenosylhomocysteinase activity
Biological Processone-carbon metabolic process
Biological Processphosphatidylcholine biosynthetic process
Biological ProcessS-adenosylhomocysteine catabolic process
Biological ProcessS-adenosylmethionine cycle
Biological Processtriglyceride metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosylhomocysteinase
  • EC number
  • Short names
    AdoHcyase
  • Alternative names
    • S-adenosyl-L-homocysteine hydrolase

Gene names

    • Name
      SAH1
    • Ordered locus names
      YER043C

Organism names

Accessions

  • Primary accession
    P39954
  • Secondary accessions
    • D3DLU3

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, cross-link.

Type
IDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00001169372-449Adenosylhomocysteinase
Cross-link21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue393Phosphothreonine
Cross-link413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P39954CAF16 P435694EBI-16451, EBI-22808

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    49,126
  • Last updated
    1995-02-01 v1
  • MD5 Checksum
    52C54CD6E1DC0A06F9E012E5B3356BF4
MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U18796
EMBL· GenBank· DDBJ
AAB64578.1
EMBL· GenBank· DDBJ
Genomic DNA
AY692801
EMBL· GenBank· DDBJ
AAT92820.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006939
EMBL· GenBank· DDBJ
DAA07697.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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