P39954 · SAHH_YEAST
- ProteinAdenosylhomocysteinase
- GeneSAH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids449 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 58 | substrate | |||
Binding site | 134 | substrate | |||
Binding site | 159 | substrate | |||
Binding site | 160-162 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 189 | substrate | |||
Binding site | 193 | substrate | |||
Binding site | 194 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 223-228 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 246 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 302-304 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 349 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | one-carbon metabolic process | |
Biological Process | phosphatidylcholine biosynthetic process | |
Biological Process | S-adenosylhomocysteine catabolic process | |
Biological Process | S-adenosylmethionine cycle | |
Biological Process | triglyceride metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Short namesAdoHcyase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP39954
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylserine | |||
Chain | PRO_0000116937 | 2-449 | Adenosylhomocysteinase | ||
Cross-link | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Modified residue | 393 | Phosphothreonine | |||
Cross-link | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P39954 | CAF16 P43569 | 4 | EBI-16451, EBI-22808 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length449
- Mass (Da)49,126
- Last updated1995-02-01 v1
- MD5 Checksum52C54CD6E1DC0A06F9E012E5B3356BF4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U18796 EMBL· GenBank· DDBJ | AAB64578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY692801 EMBL· GenBank· DDBJ | AAT92820.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006939 EMBL· GenBank· DDBJ | DAA07697.1 EMBL· GenBank· DDBJ | Genomic DNA |