P39943 · MIG3_YEAST
- ProteinTranscription corepressor MIG3
- GeneMIG3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids394 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
DNA-binding transcriptional repressor involved in response to toxic agents such as ribonucleotide reductase inhibitor, hydroxyurea (HU).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | carbon catabolite repression of transcription from RNA polymerase II promoter by glucose | |
Biological Process | cellular response to UV | |
Biological Process | DNA damage response | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | regulation of transcription from RNA polymerase II promoter by glucose | |
Biological Process | response to ethanol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription corepressor MIG3
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP39943
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000046886 | 1-394 | Transcription corepressor MIG3 | |||
Sequence: MNYLRDRFPPDNDQRPFRCEICSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTHTKGVQRRRIKSKGSRKTVVNTATAAPTTFNENTGVSLTGIGQSKVPPILISVAQNCDDVNIRNTGNNNGIVETQAPAILVPVINIPNDPHPIPSSLSTTSITSIASVYPSTSPFQYLKSGFPEDPASTPYVHSSGSSLALGELSSNSSIFSKSRRNLAAMSGPDSLSSSKNQSSASLLSQTSHPSKSFSRPPTDLSPLRRIMPSVNTGDMEISRTVSVSSSSSSLTSVTYDDTAAKDMGMGIFFDRPPVTQKACRSNHKYKVNAVSRGRQHERAQFHISGDDEDSNVHRQESRASNTSPNVSLPPIKSILRQIDNFNSAPSYFSK |
Post-translational modification
Phosphorylated during genotoxic stress. DNA damage induces phosphorylation by SNF1 or the MEC1 pathway and leads to its inactivation, which allows induction of damage response genes.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Induction
Down-regulated at low calcium levels.
Structure
Family & Domains
Features
Showing features for zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 17-39 | C2H2-type 1 | ||||
Sequence: FRCEICSRGFHRLEHKKRHGRTH | ||||||
Region | 33-52 | Disordered | ||||
Sequence: KRHGRTHTGEKPHKCTVQGC | ||||||
Zinc finger | 45-69 | C2H2-type 2 | ||||
Sequence: HKCTVQGCPKSFSRSDELKRHLRTH | ||||||
Compositional bias | 229-261 | Polar residues | ||||
Sequence: MSGPDSLSSSKNQSSASLLSQTSHPSKSFSRPP | ||||||
Region | 229-268 | Disordered | ||||
Sequence: MSGPDSLSSSKNQSSASLLSQTSHPSKSFSRPPTDLSPLR | ||||||
Compositional bias | 345-359 | Basic and acidic residues | ||||
Sequence: FHISGDDEDSNVHRQ | ||||||
Region | 345-375 | Disordered | ||||
Sequence: FHISGDDEDSNVHRQESRASNTSPNVSLPPI | ||||||
Compositional bias | 360-375 | Polar residues | ||||
Sequence: ESRASNTSPNVSLPPI |
Sequence similarities
Belongs to the creA/MIG C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length394
- Mass (Da)43,119
- Last updated1995-02-01 v1
- Checksum5218D1A0F117BEBB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 229-261 | Polar residues | ||||
Sequence: MSGPDSLSSSKNQSSASLLSQTSHPSKSFSRPP | ||||||
Compositional bias | 345-359 | Basic and acidic residues | ||||
Sequence: FHISGDDEDSNVHRQ | ||||||
Compositional bias | 360-375 | Polar residues | ||||
Sequence: ESRASNTSPNVSLPPI |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U18778 EMBL· GenBank· DDBJ | AAB64561.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006939 EMBL· GenBank· DDBJ | DAA07681.1 EMBL· GenBank· DDBJ | Genomic DNA |