P39806 · SALM_DROVI
- ProteinHomeotic protein spalt-major
- Genesalm
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1402 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHomeotic protein spalt-major
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionP39806
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047019 | 1-1402 | Homeotic protein spalt-major | |||
Sequence: MRSDFKDNHQETINKMIQFGTVKYGIVKQLKDPARSAEKDIASDQEDNGACSPLTTANASASAGNSPCPSRSPQQHSEDEREPEQVSEQELVPEVSAQSESEIGEEIENNADETNADHNHNNNNNNKLVMTKPPVEHEVEQNANLNASMPNSTTPPATNAVIAGARAQQFGATPVTLEAIQNMQMAIAQFAAKTIANGASGTDNEAAMKQLAFLQQTLFNLQQQQLFQLQLIQQLQSQLALNQVKQNDDEADEELEPEEREDGETDTYEEEERIADMELRQKAEARMAESKARQHLINAGVPYANAPDPSHQPPHRCRLRRLKRKREEDASAKSSGASAKIFGEQESSQDALNKLKEMENMPLPFGADLSSSIITNHDDLPEPNSLDLLQKRTQEVLDSASQGILANNMADDFAFGDKSSDGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPDSSPTQSPAPATGLPPPSTSTLTQMQPSMSFASSPAFPGLPGIYRPPMELLKSLGATAGSTAGLPHPFFPQMPGLGAALKHTHDQSQDMPTDLRKSSGPSSPHEEEDNIAARLPVKSELMEEEKTEHTMEAATRESAEMEPLPLEVRIKEERIDEDQMHLQEGMQKPEPLTAYATPHPQQCLIPTTHAAAKSPRSLPLQCHARLSLWCSHPTTSNHACAVLTGSQTHLDQLPTPDNVPPTMPQREDFFAERFPLNFTSKTDDHSPIRSPAGHAHAHIPRSPFFNPIKHEMAAFVPRPHSNDNSWENFIEVSNTSETMKLKELMKNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGAMPGGGAGGPPGATGMPGGPHNGTLGSESSQGDLDDNMDCGDGDDFDDISSEHLSNSNDPAATSDRRSSDDFKSLLFEQKLRIDPTGVVNINSHQRPHSAASNPNSIGSASASPSAPTSPSSQPKPSCSPVRSSCSPVRSVSETSQGALDLTPRALPPPLASSSSRSPYRQLLSVRRRPLARSVSSHRCVVPMVRALLSSQLPPSVGIDCLPPGLQHHLQQQHQHLMQQQXAVAAAAAAQHHHHQMQQHAAALHQHQEHLRREAQEVQQKAAQEVQQKAAAAAAAAAAAQRQESPQPPPRSGESSVGPPAQPNPLISARPPFGMFPNLPIFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCNICDRGFTTKGNLKQHMLTHKIRDMEQETFRNRAVK |
Expression
Developmental stage
First expressed at blastoderm stage and later in restricted aeras of the embryonic nervous system as well as in the developing trachea.
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 24-158 | Disordered | ||||
Sequence: YGIVKQLKDPARSAEKDIASDQEDNGACSPLTTANASASAGNSPCPSRSPQQHSEDEREPEQVSEQELVPEVSAQSESEIGEEIENNADETNADHNHNNNNNNKLVMTKPPVEHEVEQNANLNASMPNSTTPPAT | ||||||
Compositional bias | 48-73 | Polar residues | ||||
Sequence: NGACSPLTTANASASAGNSPCPSRSP | ||||||
Compositional bias | 74-88 | Basic and acidic residues | ||||
Sequence: QQHSEDEREPEQVSE | ||||||
Compositional bias | 116-130 | Polar residues | ||||
Sequence: ADHNHNNNNNNKLVM | ||||||
Compositional bias | 141-158 | Polar residues | ||||
Sequence: QNANLNASMPNSTTPPAT | ||||||
Region | 244-268 | Disordered | ||||
Sequence: VKQNDDEADEELEPEEREDGETDTY | ||||||
Compositional bias | 249-268 | Acidic residues | ||||
Sequence: DEADEELEPEEREDGETDTY | ||||||
Zinc finger | 432-454 | C2H2-type 1 | ||||
Sequence: HRCRYCGKVFGSDSALQIHIRSH | ||||||
Zinc finger | 460-482 | C2H2-type 2 | ||||
Sequence: FKCNVCGSRFTTKGNLKVHFQRH | ||||||
Region | 489-647 | Disordered | ||||
Sequence: VPMNATPIPEHMDKFHPPLLDQMSPDSSPTQSPAPATGLPPPSTSTLTQMQPSMSFASSPAFPGLPGIYRPPMELLKSLGATAGSTAGLPHPFFPQMPGLGAALKHTHDQSQDMPTDLRKSSGPSSPHEEEDNIAARLPVKSELMEEEKTEHTMEAATR | ||||||
Compositional bias | 529-546 | Polar residues | ||||
Sequence: PPSTSTLTQMQPSMSFAS | ||||||
Compositional bias | 611-647 | Basic and acidic residues | ||||
Sequence: GPSSPHEEEDNIAARLPVKSELMEEEKTEHTMEAATR | ||||||
Region | 771-794 | Disordered | ||||
Sequence: SKTDDHSPIRSPAGHAHAHIPRSP | ||||||
Zinc finger | 845-867 | C2H2-type 3 | ||||
Sequence: NQCVVCDRVLSCKSALQMHYRTH | ||||||
Zinc finger | 873-895 | C2H2-type 4 | ||||
Sequence: FKCRICGRAFTTKGNLKTHMAVH | ||||||
Zinc finger | 905-927 | C2H2-type 5 | ||||
Sequence: HQCPVCHKKYSNALVLQQHIRLH | ||||||
Region | 967-1035 | Disordered | ||||
Sequence: FGAMPGGGAGGPPGATGMPGGPHNGTLGSESSQGDLDDNMDCGDGDDFDDISSEHLSNSNDPAATSDRR | ||||||
Compositional bias | 1055-1086 | Polar residues | ||||
Sequence: GVVNINSHQRPHSAASNPNSIGSASASPSAPT | ||||||
Region | 1055-1136 | Disordered | ||||
Sequence: GVVNINSHQRPHSAASNPNSIGSASASPSAPTSPSSQPKPSCSPVRSSCSPVRSVSETSQGALDLTPRALPPPLASSSSRSP | ||||||
Compositional bias | 1093-1117 | Polar residues | ||||
Sequence: KPSCSPVRSSCSPVRSVSETSQGAL | ||||||
Region | 1205-1290 | Disordered | ||||
Sequence: AAAQHHHHQMQQHAAALHQHQEHLRREAQEVQQKAAQEVQQKAAAAAAAAAAAQRQESPQPPPRSGESSVGPPAQPNPLISARPPF | ||||||
Compositional bias | 1222-1236 | Basic and acidic residues | ||||
Sequence: HQHQEHLRREAQEVQ | ||||||
Compositional bias | 1262-1279 | Polar residues | ||||
Sequence: SPQPPPRSGESSVGPPAQ | ||||||
Zinc finger | 1336-1358 | C2H2-type 6 | ||||
Sequence: TTCGICYKTFPCHSALEIHYRSH | ||||||
Zinc finger | 1364-1386 | C2H2-type 7 | ||||
Sequence: FKCNICDRGFTTKGNLKQHMLTH |
Sequence similarities
Belongs to the sal C2H2-type zinc-finger protein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,402
- Mass (Da)153,746
- Last updated1995-02-01 v1
- Checksum4CDB2EE384F70AE5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 48-73 | Polar residues | ||||
Sequence: NGACSPLTTANASASAGNSPCPSRSP | ||||||
Compositional bias | 74-88 | Basic and acidic residues | ||||
Sequence: QQHSEDEREPEQVSE | ||||||
Compositional bias | 116-130 | Polar residues | ||||
Sequence: ADHNHNNNNNNKLVM | ||||||
Compositional bias | 141-158 | Polar residues | ||||
Sequence: QNANLNASMPNSTTPPAT | ||||||
Compositional bias | 249-268 | Acidic residues | ||||
Sequence: DEADEELEPEEREDGETDTY | ||||||
Compositional bias | 529-546 | Polar residues | ||||
Sequence: PPSTSTLTQMQPSMSFAS | ||||||
Compositional bias | 611-647 | Basic and acidic residues | ||||
Sequence: GPSSPHEEEDNIAARLPVKSELMEEEKTEHTMEAATR | ||||||
Compositional bias | 1055-1086 | Polar residues | ||||
Sequence: GVVNINSHQRPHSAASNPNSIGSASASPSAPT | ||||||
Compositional bias | 1093-1117 | Polar residues | ||||
Sequence: KPSCSPVRSSCSPVRSVSETSQGAL | ||||||
Compositional bias | 1222-1236 | Basic and acidic residues | ||||
Sequence: HQHQEHLRREAQEVQ | ||||||
Compositional bias | 1262-1279 | Polar residues | ||||
Sequence: SPQPPPRSGESSVGPPAQ |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z27444 EMBL· GenBank· DDBJ | CAA81800.1 EMBL· GenBank· DDBJ | mRNA |