P39722 · GEM1_YEAST
- ProteinMitochondrial Rho GTPase 1
- GeneGEM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids662 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12-19 | GTP 1 (UniProtKB | ChEBI) | |||
Binding site | 62-64 | GTP 1 (UniProtKB | ChEBI) | |||
Binding site | 116-119 | GTP 1 (UniProtKB | ChEBI) | |||
Binding site | 214 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 216 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 218 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 220 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 225 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 343 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 345 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 347 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 354 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 455-462 | GTP 2 (UniProtKB | ChEBI) | |||
Binding site | 491-495 | GTP 2 (UniProtKB | ChEBI) | |||
Binding site | 560-563 | GTP 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | ERMES complex | |
Cellular Component | mitochondria-associated endoplasmic reticulum membrane contact site | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | mitochondrion | |
Cellular Component | outer mitochondrial membrane protein complex | |
Molecular Function | calcium ion binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | heme transport | |
Biological Process | mitochondrion inheritance | |
Biological Process | mitochondrion organization | |
Biological Process | mitochondrion-endoplasmic reticulum membrane tethering | |
Biological Process | phospholipid homeostasis | |
Biological Process | regulation of mitochondrion organization | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitochondrial Rho GTPase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP39722
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-634 | Cytoplasmic | |||
Transmembrane | 635-655 | Helical; Anchor for type IV membrane protein | |||
Topological domain | 656-662 | Mitochondrial intermembrane | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Collapsed, globular, or grape-like mitochondria.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 18 | Loss of function. | |||
Mutagenesis | 19 | Loss of function. | |||
Mutagenesis | 33 | No effect. | |||
Mutagenesis | 225 | Induces collapsed, globular or grape-like mitochondria; when associated with A-354. | |||
Mutagenesis | 354 | Induces collapsed, globular or grape-like mitochondria; when associated with A-225. | |||
Mutagenesis | 461 | Induces collapsed, globular or grape-like mitochondria. | |||
Mutagenesis | 462 | Induces collapsed, globular or grape-like mitochondria. | |||
Mutagenesis | 480 | Induces collapsed, globular or grape-like mitochondria. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000202422 | 1-662 | Mitochondrial Rho GTPase 1 | ||
Proteomic databases
PTM databases
Interaction
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-185 | Miro 1 | |||
Domain | 201-236 | EF-hand 1 | |||
Domain | 330-365 | EF-hand 2 | |||
Domain | 446-611 | Miro 2 | |||
Sequence similarities
Belongs to the mitochondrial Rho GTPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length662
- Mass (Da)75,150
- Last updated1995-02-01 v1
- ChecksumA68CDA15D79E5910
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U12980 EMBL· GenBank· DDBJ | AAC04983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006935 EMBL· GenBank· DDBJ | DAA06938.1 EMBL· GenBank· DDBJ | Genomic DNA |