P39722 · GEM1_YEAST

Function

function

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable).

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site12-19GTP 1 (UniProtKB | ChEBI)
Binding site62-64GTP 1 (UniProtKB | ChEBI)
Binding site116-119GTP 1 (UniProtKB | ChEBI)
Binding site214Ca2+ 1 (UniProtKB | ChEBI)
Binding site216Ca2+ 1 (UniProtKB | ChEBI)
Binding site218Ca2+ 1 (UniProtKB | ChEBI)
Binding site220Ca2+ 1 (UniProtKB | ChEBI)
Binding site225Ca2+ 1 (UniProtKB | ChEBI)
Binding site343Ca2+ 2 (UniProtKB | ChEBI)
Binding site345Ca2+ 2 (UniProtKB | ChEBI)
Binding site347Ca2+ 2 (UniProtKB | ChEBI)
Binding site354Ca2+ 2 (UniProtKB | ChEBI)
Binding site455-462GTP 2 (UniProtKB | ChEBI)
Binding site491-495GTP 2 (UniProtKB | ChEBI)
Binding site560-563GTP 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentERMES complex
Cellular Componentmitochondria-associated endoplasmic reticulum membrane contact site
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Cellular Componentouter mitochondrial membrane protein complex
Molecular Functioncalcium ion binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processheme transport
Biological Processmitochondrion inheritance
Biological Processmitochondrion organization
Biological Processmitochondrion-endoplasmic reticulum membrane tethering
Biological Processphospholipid homeostasis
Biological Processregulation of mitochondrion organization
Biological Processsmall GTPase-mediated signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial Rho GTPase 1
  • EC number
  • Alternative names
    • GTPase EF-hand protein of mitochondria 1

Gene names

    • Name
      GEM1
    • Ordered locus names
      YAL048C

Organism names

Accessions

  • Primary accession
    P39722
  • Secondary accessions
    • D6VPG8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-634Cytoplasmic
Transmembrane635-655Helical; Anchor for type IV membrane protein
Topological domain656-662Mitochondrial intermembrane

Keywords

Phenotypes & Variants

Disruption phenotype

Collapsed, globular, or grape-like mitochondria.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis18Loss of function.
Mutagenesis19Loss of function.
Mutagenesis33No effect.
Mutagenesis225Induces collapsed, globular or grape-like mitochondria; when associated with A-354.
Mutagenesis354Induces collapsed, globular or grape-like mitochondria; when associated with A-225.
Mutagenesis461Induces collapsed, globular or grape-like mitochondria.
Mutagenesis462Induces collapsed, globular or grape-like mitochondria.
Mutagenesis480Induces collapsed, globular or grape-like mitochondria.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002024221-662Mitochondrial Rho GTPase 1

Proteomic databases

PTM databases

Interaction

Complex viewer

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-185Miro 1
Domain201-236EF-hand 1
Domain330-365EF-hand 2
Domain446-611Miro 2

Sequence similarities

Belongs to the mitochondrial Rho GTPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    662
  • Mass (Da)
    75,150
  • Last updated
    1995-02-01 v1
  • Checksum
    A68CDA15D79E5910
MTKETIRVVICGDEGVGKSSLIVSLTKAEFIPTIQDVLPPISIPRDFSSSPTYSPKNTVLIDTSDSDLIALDHELKSADVIWLVYCDHESYDHVSLFWLPHFRSLGLNIPVILCKNKCDSISNVNANAMVVSENSDDDIDTKVEDEEFIPILMEFKEIDTCIKTSAKTQFDLNQAFYLCQRAITHPISPLFDAMVGELKPLAVMALKRIFLLSDLNQDSYLDDNEILGLQKKCFNKSIDVNELNFIKDLLLDISKHDQEYINRKLYVPGKGITKDGFLVLNKIYAERGRHETTWAILRTFHYTDSLCINDKILHPRLVVPDTSSVELSPKGYRFLVDIFLKFDIDNDGGLNNQELHRLFKCTPGLPKLWTSTNFPFSTVVNNKGCITLQGWLAQWSMTTFLNYSTTTAYLVYFGFQEDARLALQVTKPRKMRRRSGKLYRSNINDRKVFNCFVIGKPCCGKSSLLEAFLGRSFSEEYSPTIKPRIAVNSLELKGGKQYYLILQELGEQEYAILENKDKLKECDVICLTYDSSDPESFSYLVSLLDKFTHLQDLPLVFVASKADLDKQQQRCQIQPDELADELFVNHPLHISSRWLSSLNELFIKITEAALDPGKNTPGLPEETAAKDVDYRQTALIFGSTVGFVALCSFTLMKLFKSSKFSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U12980
EMBL· GenBank· DDBJ
AAC04983.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006935
EMBL· GenBank· DDBJ
DAA06938.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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