P39431 · NCPP_ENTCL
- ProteinInosine/xanthosine triphosphatase
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity
- XTP + H2O = XDP + phosphate + H+
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ITPase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | thiamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine/xanthosine triphosphatase
- EC number
- Short namesITPase/XTPase
- Alternative names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex
Accessions
- Primary accessionP39431
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000156341 | 1-67 | Inosine/xanthosine triphosphatase | |||
Sequence: PLPEIILNKVREGEALGPVMSQYTGIDEIGRKEGAIGVFTKGVLTRSGVYHQAVVLALSPFHNAIYR |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusFragment
- Length67
- Mass (Da)7,278
- Last updated1995-02-01 v1
- Checksum926E6E8DDB375D03
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: P |