P39431 · NCPP_ENTCL

  • Protein
    Inosine/xanthosine triphosphatase
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

GO annotations

AspectTerm
Molecular FunctionITPase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processthiamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine/xanthosine triphosphatase
  • EC number
  • Short names
    ITPase/XTPase
  • Alternative names
    • Non-canonical purine NTP phosphatase
    • Non-standard purine NTP phosphatase
    • Nucleoside-triphosphate phosphatase
      (NTPase
      )

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    P39431

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001563411-67Inosine/xanthosine triphosphatase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the YjjX NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    67
  • Mass (Da)
    7,278
  • Last updated
    1995-02-01 v1
  • Checksum
    926E6E8DDB375D03
PLPEIILNKVREGEALGPVMSQYTGIDEIGRKEGAIGVFTKGVLTRSGVYHQAVVLALSPFHNAIYR

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L26583
EMBL· GenBank· DDBJ
AAA20184.1
EMBL· GenBank· DDBJ
Unassigned DNA

Similar Proteins

Disclaimer

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