P39413 · AEF1_DROME
- ProteinAdult enhancer factor 1
- GeneAef1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids308 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Transcriptional repressor that binds specifically to fat body-specific enhancers, namely the adult ADH enhancer (AAE) and the enhancer that controls yolk protein gene expression.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdult enhancer factor 1
- Short namesAEF-1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP39413
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000046908 | 1-308 | Adult enhancer factor 1 | |||
Sequence: MMHIKSLPHAHAAATAMSSNCDIVIVAAQPQTTIANNNNNETVTQATHPAHMAAVQQQQQQQQQQQQQHHQQQQQQSSGPPSVPPPPTELPLPFQMHLSGISAEAHSAAQAAAMAAAQAAAAQAAAAEQQQPPPPTSHLTHLTTHSPTTIHSEHYLANGHSEHPGEGNAAVGVGGAVREPEKPFHCTVCDRRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYNCNFCPKHFRQLSTLANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEG |
Proteomic databases
Expression
Tissue specificity
Found in all tissues examined including the ovary and the fat body.
Developmental stage
Higher levels are found in third-instar larvae and in adults.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 50-78 | Polar residues | ||||
Sequence: AHMAAVQQQQQQQQQQQQQHHQQQQQQSS | ||||||
Region | 50-94 | Disordered | ||||
Sequence: AHMAAVQQQQQQQQQQQQQHHQQQQQQSSGPPSVPPPPTELPLPF | ||||||
Region | 123-143 | Disordered | ||||
Sequence: QAAAAEQQQPPPPTSHLTHLT | ||||||
Compositional bias | 129-143 | Polar residues | ||||
Sequence: QQQPPPPTSHLTHLT | ||||||
Zinc finger | 184-206 | C2H2-type 1 | ||||
Sequence: FHCTVCDRRFRQLSTLTNHVKIH | ||||||
Zinc finger | 212-234 | C2H2-type 2 | ||||
Sequence: YKCNVCDKTFRQSSTLTNHLKIH | ||||||
Zinc finger | 240-262 | C2H2-type 3 | ||||
Sequence: YNCNFCPKHFRQLSTLANHVKIH | ||||||
Zinc finger | 268-290 | C2H2-type 4 | ||||
Sequence: FECVICKKQFRQSSTLNNHIKIH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length308
- Mass (Da)33,782
- Last updated1995-02-01 v1
- Checksum54F04D90B6FC4250
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 50-78 | Polar residues | ||||
Sequence: AHMAAVQQQQQQQQQQQQQHHQQQQQQSS | ||||||
Compositional bias | 129-143 | Polar residues | ||||
Sequence: QQQPPPPTSHLTHLT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M90755 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AE014296 EMBL· GenBank· DDBJ | AAF51721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY060435 EMBL· GenBank· DDBJ | AAL25474.1 EMBL· GenBank· DDBJ | mRNA |