P38960 · STN1_YEAST

Function

function

Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.

Features

Showing features for dna binding.

149450100150200250300350400450
TypeIDPosition(s)Description
DNA binding62-159OB

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentCST complex
Molecular Functionsingle-stranded telomeric DNA binding
Molecular Functiontranslation elongation factor binding
Biological Processnegative regulation of telomere maintenance via telomerase
Biological Processregulation of telomere maintenance via telomerase
Biological Processtelomere capping

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein STN1

Gene names

    • Name
      STN1
    • ORF names
      D4456, YD8554.15
    • Ordered locus names
      YDR082W

Organism names

Accessions

  • Primary accession
    P38960
  • Secondary accessions
    • D6VS69

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis397Modest telomere elongation phenotype.
Mutagenesis466Elongated telomeres.
Mutagenesis466Elongated telomeres and severe growth defects.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000722791-494Protein STN1

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with CDC13 and TEN1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P38960CDC13 P3279710EBI-18427, EBI-4187
BINARY P38960POL12 P381212EBI-18427, EBI-6111
BINARY P38960TEN1 Q0792112EBI-18427, EBI-35131

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region311-397Winged helix-turn-helix (wHTH) 1
Region396-494Winged helix-turn-helix (wHTH) 2

Domain

The C-terminal wHLH region seems to mediate telomere-specific function.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    494
  • Mass (Da)
    57,511
  • Last updated
    1995-02-01 v1
  • Checksum
    61B691C8D4A2E650
MDKYGHIAHQEGDVCYYIPRLFKYNSYYSGTEDVRIFVGDLKYRMRVSLQICEKYYDRRLSMLFWKNHPLQQIHLIGCIIGLQFKWIGKQEYIFFQLDDCTSDSSLVGYTSDMRFLTCKVKKDSILSWGLNITDLIGLTLHVYGQASLNYQELQVEYLRLCYSLTEEIDHWKITMNMREQLDTPWSLSDFVIGELFTQEQEWTPETSQIEVVNPDFVGIGYKTPESKRNETTFIEQLQEERLKDELEIISPYNSTDTSNSVHSLSFRFVSSLKDFPETHFLNSGDQIDNGNDEQLKKLEYQSANLPVMIPNRTSAKSNLMLILLGLQMKEISNSDLYKLKEVRSVVTSLASFLFQQQNVGVMKSFDSLEKEAFRDLVNRLVSQGLIGLKDKTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLPYITTNGIVDVFKECLKRTKKQYPEVLKNWWIDLDPKNGMEDQNSGILLHLEYAAAYS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF002132
EMBL· GenBank· DDBJ
AAB60885.1
EMBL· GenBank· DDBJ
Genomic DNA
X82086
EMBL· GenBank· DDBJ
CAA57609.1
EMBL· GenBank· DDBJ
Genomic DNA
Z46796
EMBL· GenBank· DDBJ
CAA86804.1
EMBL· GenBank· DDBJ
Genomic DNA
Z74378
EMBL· GenBank· DDBJ
CAA98902.1
EMBL· GenBank· DDBJ
Genomic DNA
AY723774
EMBL· GenBank· DDBJ
AAU09691.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006938
EMBL· GenBank· DDBJ
DAA11929.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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