P38903 · 2A5D_YEAST
- ProteinSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
- GeneRTS1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids757 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Multicopy suppressor of ROX3 and HSP60.
Miscellaneous
Present with 300 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cellular bud neck | |
Cellular Component | cytoplasm | |
Cellular Component | kinetochore | |
Cellular Component | nucleus | |
Cellular Component | protein phosphatase type 2A complex | |
Cellular Component | spindle pole body | |
Molecular Function | DNA binding | |
Molecular Function | protein phosphatase regulator activity | |
Biological Process | cellular bud neck septin ring organization | |
Biological Process | DNA repair | |
Biological Process | establishment of protein localization to chromosome | |
Biological Process | meiotic sister chromatid cohesion, centromeric | |
Biological Process | mitotic spindle orientation checkpoint signaling | |
Biological Process | positive regulation of autophagosome assembly | |
Biological Process | protein localization | |
Biological Process | septin ring disassembly | |
Biological Process | sister chromatid biorientation |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP38903
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000071471 | 1-757 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | ||
Modified residue | 242 | Phosphothreonine | |||
Modified residue | 257 | Phosphothreonine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-172 | Disordered | |||
Compositional bias | 21-37 | Basic and acidic residues | |||
Compositional bias | 38-162 | Polar residues | |||
Compositional bias | 188-243 | Polar residues | |||
Region | 188-250 | Disordered | |||
Region | 734-757 | Disordered | |||
Sequence similarities
Belongs to the phosphatase 2A regulatory subunit B family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length757
- Mass (Da)85,335
- Last updated1996-10-01 v2
- Checksum5A7476C30140331C
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 21-37 | Basic and acidic residues | |||
Compositional bias | 38-162 | Polar residues | |||
Sequence conflict | 95 | in Ref. 2; AAB35312 | |||
Compositional bias | 188-243 | Polar residues | |||
Sequence conflict | 529 | in Ref. 1; AAB38372 | |||
Sequence conflict | 581 | in Ref. 1; AAB38372 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U06630 EMBL· GenBank· DDBJ | AAB38372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
S79635 EMBL· GenBank· DDBJ | AAB35312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X87331 EMBL· GenBank· DDBJ | CAA60763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74922 EMBL· GenBank· DDBJ | CAA99203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006948 EMBL· GenBank· DDBJ | DAA10797.1 EMBL· GenBank· DDBJ | Genomic DNA |