P38903 · 2A5D_YEAST

Function

function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Multicopy suppressor of ROX3 and HSP60.

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcellular bud neck
Cellular Componentcytoplasm
Cellular Componentkinetochore
Cellular Componentnucleus
Cellular Componentprotein phosphatase type 2A complex
Cellular Componentspindle pole body
Molecular FunctionDNA binding
Molecular Functionprotein phosphatase regulator activity
Biological Processcellular bud neck septin ring organization
Biological ProcessDNA repair
Biological Processestablishment of protein localization to chromosome
Biological Processmeiotic sister chromatid cohesion, centromeric
Biological Processmitotic spindle orientation checkpoint signaling
Biological Processpositive regulation of autophagosome assembly
Biological Processprotein localization
Biological Processseptin ring disassembly
Biological Processsister chromatid biorientation

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
  • Alternative names
    • PP2A, B subunit, B' delta isoform
    • Protein RTS1
    • Protein SCS1

Gene names

    • Name
      RTS1
    • Synonyms
      SCS1
    • ORF names
      OR26.04
    • Ordered locus names
      YOR014W

Organism names

Accessions

  • Primary accession
    P38903
  • Secondary accessions
    • D6W281

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000714711-757Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Modified residue242Phosphothreonine
Modified residue257Phosphothreonine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Complex viewer

View interactors in UniProtKB
View CPX-1857 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-172Disordered
Compositional bias21-37Basic and acidic residues
Compositional bias38-162Polar residues
Compositional bias188-243Polar residues
Region188-250Disordered
Region734-757Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    757
  • Mass (Da)
    85,335
  • Last updated
    1996-10-01 v2
  • Checksum
    5A7476C30140331C
MMRGFKQRLIKKTTGSSSSSSSKKKDKEKEKEKSSTTSSTSKKPASASSSSHGTTHSSASSTGSKSTTEKGKQSGSVPSQGKHHSSSTSKTKTATTPSSSSSSSRSSSVSRSGSSSTKKTSSRKGQEQSKQSQQPSQSQKQGSSSSSAAIMNPTPVLTVTKDDKSTSGEDHAHPTLLGAVSAVPSSPISNASGTAVSSDVENGNSNNNNMNINTSNTQDANHASSQSIDIPRSSHSFERLPTPTKLNPDTDLELIKTPQRHSSSRFEPSRYTPLTKLPNFNEVSPEERIPLFIAKVDQCNTMFDFNDPSFDIQGKEIKRSTLDELIEFLVTNRFTYTNEMYAHVVNMFKINLFRPIPPPVNPVGDIYDPDEDEPVNELAWPHMQAVYEFFLRFVESPDFNHQIAKQYIDQDFILKLLELFDSEDIRERDCLKTTLHRIYGKFLSLRSFIRRSMNNIFLQFIYETEKFNGVAELLEILGSIINGFALPLKEEHKVFLVRILIPLHKVRCLSLYHPQLAYCIVQFLEKDPLLTEEVVMGLLRYWPKINSTKEIMFLNEIEDIFEVIEPLEFIKVEVPLFVQLAKCISSPHFQVAEKVLSYWNNEYFLNLCIENAEVILPIIFPALYELTSQLELDTANGEDSISDPYMLVEQAINSGSWNRAIHAMAFKALKIFLETNPVLYENCNALYLSSVKETQQRKVQREENWSKLEEYVKNLRINNDKDQYTIKNPELRNSFNTASENNTLNEENENDCDSEIQ

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias21-37Basic and acidic residues
Compositional bias38-162Polar residues
Sequence conflict95in Ref. 2; AAB35312
Compositional bias188-243Polar residues
Sequence conflict529in Ref. 1; AAB38372
Sequence conflict581in Ref. 1; AAB38372

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U06630
EMBL· GenBank· DDBJ
AAB38372.1
EMBL· GenBank· DDBJ
Genomic DNA
S79635
EMBL· GenBank· DDBJ
AAB35312.1
EMBL· GenBank· DDBJ
Genomic DNA
X87331
EMBL· GenBank· DDBJ
CAA60763.1
EMBL· GenBank· DDBJ
Genomic DNA
Z74922
EMBL· GenBank· DDBJ
CAA99203.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006948
EMBL· GenBank· DDBJ
DAA10797.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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