P38857 · MPC2_YEAST
- ProteinMitochondrial pyruvate carrier 2
- GeneMPC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids129 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mediates the uptake of pyruvate into mitochondria.
Miscellaneous
Present with 3410 molecules/cell in log phase SD medium.
Catalytic activity
- H+(out) + pyruvate(out) = H+(in) + pyruvate(in)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | inner mitochondrial membrane protein complex | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Molecular Function | pyruvate transmembrane transporter activity | |
Biological Process | mitochondrial pyruvate transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMitochondrial pyruvate carrier 2
- Short namesMPC2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP38857
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 2-22 | Mitochondrial matrix | ||||
Sequence: STSSVRFAFRRFWQSETGPKT | ||||||
Transmembrane | 23-39 | Helical | ||||
Sequence: VHFWAPTLKWGLVFAGF | ||||||
Topological domain | 40-54 | Mitochondrial intermembrane | ||||
Sequence: SDMKRPVEKISGAQN | ||||||
Transmembrane | 55-71 | Helical | ||||
Sequence: LSLLSTALIWTRWSFVI | ||||||
Topological domain | 72-74 | Mitochondrial matrix | ||||
Sequence: KPR | ||||||
Transmembrane | 75-91 | Helical | ||||
Sequence: NILLASVNSFLCLTAGY | ||||||
Topological domain | 92-129 | Mitochondrial intermembrane | ||||
Sequence: QLGRIANYRIRNGDSISQLCSYILSGADESKKEITTGR |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Grows more slowly in amino acid-free medium (SD), when combined with disruption of MPC3.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000212801 | 1-129 | Mitochondrial pyruvate carrier 2 | |||
Sequence: MSTSSVRFAFRRFWQSETGPKTVHFWAPTLKWGLVFAGFSDMKRPVEKISGAQNLSLLSTALIWTRWSFVIKPRNILLASVNSFLCLTAGYQLGRIANYRIRNGDSISQLCSYILSGADESKKEITTGR |
Proteomic databases
Expression
Induction
Mainly expressed when grown on glucose containing growth medium.
Interaction
Subunit
The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and either MPC2 or MPC3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P38857 | MPC1 P53157 | 9 | EBI-24818, EBI-23845 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length129
- Mass (Da)14,555
- Last updated1995-02-01 v1
- Checksum5C1FB3A463DE24A7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U00027 EMBL· GenBank· DDBJ | AAB68009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY558303 EMBL· GenBank· DDBJ | AAS56629.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006934 EMBL· GenBank· DDBJ | DAA06855.1 EMBL· GenBank· DDBJ | Genomic DNA |