P38857 · MPC2_YEAST

Function

function

Mediates the uptake of pyruvate into mitochondria.

Miscellaneous

Present with 3410 molecules/cell in log phase SD medium.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentinner mitochondrial membrane protein complex
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Molecular Functionpyruvate transmembrane transporter activity
Biological Processmitochondrial pyruvate transmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial pyruvate carrier 2
  • Short names
    MPC2

Gene names

    • Name
      MPC2
    • Ordered locus names
      YHR162W

Organism names

Accessions

  • Primary accession
    P38857
  • Secondary accessions
    • D3DLB1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-22Mitochondrial matrix
Transmembrane23-39Helical
Topological domain40-54Mitochondrial intermembrane
Transmembrane55-71Helical
Topological domain72-74Mitochondrial matrix
Transmembrane75-91Helical
Topological domain92-129Mitochondrial intermembrane

Keywords

Phenotypes & Variants

Disruption phenotype

Grows more slowly in amino acid-free medium (SD), when combined with disruption of MPC3.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002128011-129Mitochondrial pyruvate carrier 2

Proteomic databases

Expression

Induction

Mainly expressed when grown on glucose containing growth medium.

Interaction

Subunit

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and either MPC2 or MPC3.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P38857MPC1 P531579EBI-24818, EBI-23845
View interactors in UniProtKB
View CPX-302 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    129
  • Mass (Da)
    14,555
  • Last updated
    1995-02-01 v1
  • Checksum
    5C1FB3A463DE24A7
MSTSSVRFAFRRFWQSETGPKTVHFWAPTLKWGLVFAGFSDMKRPVEKISGAQNLSLLSTALIWTRWSFVIKPRNILLASVNSFLCLTAGYQLGRIANYRIRNGDSISQLCSYILSGADESKKEITTGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U00027
EMBL· GenBank· DDBJ
AAB68009.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558303
EMBL· GenBank· DDBJ
AAS56629.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006934
EMBL· GenBank· DDBJ
DAA06855.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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