P38815 · YPT35_YEAST

Function

function

Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular Componentnucleus-vacuole junction
Cellular Componentvacuolar membrane
Molecular Functionphosphatidylinositol-3-phosphate binding
Molecular Functionprotein-macromolecule adaptor activity
Biological Processprotein localization to endosome
Biological Processprotein localization to membrane

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endosomal/vacuolar adapter protein YPT35
  • Alternative names
    • PX domain-containing protein YPT35

Gene names

    • Name
      YPT35
    • Ordered locus names
      YHR105W

Organism names

Accessions

  • Primary accession
    P38815
  • Secondary accessions
    • D3DL55

Proteomes

Organism-specific databases

Subcellular Location

Endosome membrane
; Peripheral membrane protein
Vacuole membrane
; Peripheral membrane protein
Note: Localizes to nuclear envelope-vacuole contact sites during respiration.

Keywords

Phenotypes & Variants

Disruption phenotype

Decreases VPS13 levels at endosomal membranes and nuclear envelope-vacuole contact sites.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis5Disrupts interaction with VPS13.
Mutagenesis5-15Disrupts interaction with VPS13.
Mutagenesis8Disrupts interaction with VPS13.
Mutagenesis10Disrupts interaction with VPS13.
Mutagenesis12Disrupts interaction with VPS13.
Mutagenesis13Disrupts interaction with VPS13.
Mutagenesis15Disrupts interaction with VPS13.
Mutagenesis123Abolishes partially PtdIns3P-binding.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002029101-214Endosomal/vacuolar adapter protein YPT35
Modified residue65Phosphoserine
Modified residue66Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts (via PxP motif) with VPS13 (via SHR-BD domain) (PubMed:30018089).
Interacts with RBD2 (PubMed:15263065).
Interacts with YIF1 (PubMed:15263065).
Interacts with YIP1 (PubMed:15263065).
Interacts with YIP4 (PubMed:15263065).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P38815YIF1 P538454EBI-24665, EBI-28230
BINARY P38815YIP1 P530393EBI-24665, EBI-25295
BINARY P38815YIP4 P530932EBI-24665, EBI-24124

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, motif, compositional bias, domain.

TypeIDPosition(s)Description
Region1-63Disordered
Motif5-15PxP
Compositional bias31-63Polar residues
Domain73-213PX

Domain

The PX domain binds phosphatidylinositol 3-phosphate (PtdIns3P) which is necessary for peripheral membrane localization.

Sequence similarities

Belongs to the YPT35 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    24,646
  • Last updated
    1995-02-01 v1
  • Checksum
    2ADD21AF107094DC
MSDKISFLPPEPIQLLDEDSTEPELDIDSQQENEGPISASNSNDSTSHSNDCGATITRTRPRRSSSINANFSFQKAHVSDCTIVNGDHGTKFAVWRITVFLEPNLKAFAAKRESYKIQTYKRYSDFVRLRENLLTRIKTAKPEKLNCLQIPHLPPSVQWYSSWKYQEVNLNKDWLAKRQRGLEYFLNHIILNSSLVEMTKDILIQFLEPSKRVA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias31-63Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U00059
EMBL· GenBank· DDBJ
AAB68857.1
EMBL· GenBank· DDBJ
Genomic DNA
AY557854
EMBL· GenBank· DDBJ
AAS56180.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006934
EMBL· GenBank· DDBJ
DAA06799.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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