P38636 · ATX1_YEAST
- ProteinCopper chaperone ATX1
- GeneATX1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Copper homeostasis factor that specifically transports copper to the secretory pathway for incorporation into copper enzymes destined for the cell surface or extracellular milieu (PubMed:9346482).
Shuttles copper to the transport ATPase CCC2 on a post-Golgi vesicle for eventual targeting to the cell-surface high-affinity iron uptake protein FET3 (PubMed:11327811, PubMed:16732294, PubMed:9083054, PubMed:9346482).
Protects against oxygen toxicity (PubMed:7731983).
Shuttles copper to the transport ATPase CCC2 on a post-Golgi vesicle for eventual targeting to the cell-surface high-affinity iron uptake protein FET3 (PubMed:11327811, PubMed:16732294, PubMed:9083054, PubMed:9346482).
Protects against oxygen toxicity (PubMed:7731983).
Activity regulation
Tetrathiomolybdate directly and reversibly down-regulates copper delivery to secreted metalloenzymes.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 15 | Cu+ (UniProtKB | ChEBI) | |||
Binding site | 18 | Cu+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | copper chaperone activity | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to oxidative stress | |
Biological Process | copper ion transport | |
Biological Process | intracellular iron ion homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCopper chaperone ATX1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP38636
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000212535 | 1-73 | Copper chaperone ATX1 | ||
Proteomic databases
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length73
- Mass (Da)8,221
- Last updated1994-10-01 v1
- Checksum9BDF0B542F80EA83
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 8 | in Ref. 5; AAS56693 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L35270 EMBL· GenBank· DDBJ | AAC37428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X96722 EMBL· GenBank· DDBJ | CAA65485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z71535 EMBL· GenBank· DDBJ | CAA96166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY558367 EMBL· GenBank· DDBJ | AAS56693.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006947 EMBL· GenBank· DDBJ | DAA10300.1 EMBL· GenBank· DDBJ | Genomic DNA |