P38636 · ATX1_YEAST

Function

function

Copper homeostasis factor that specifically transports copper to the secretory pathway for incorporation into copper enzymes destined for the cell surface or extracellular milieu (PubMed:9346482).
Shuttles copper to the transport ATPase CCC2 on a post-Golgi vesicle for eventual targeting to the cell-surface high-affinity iron uptake protein FET3 (PubMed:11327811, PubMed:16732294, PubMed:9083054, PubMed:9346482).
Protects against oxygen toxicity (PubMed:7731983).

Activity regulation

Tetrathiomolybdate directly and reversibly down-regulates copper delivery to secreted metalloenzymes.

Features

Showing features for binding site.

17310203040506070MAEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQLVDVYTTLPYDFILEKIKKTGKEVRSGKQL
TypeIDPosition(s)Description
Binding site15Cu+ (UniProtKB | ChEBI)
Binding site18Cu+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncopper chaperone activity
Molecular Functionmetal ion binding
Biological Processcellular response to oxidative stress
Biological Processcopper ion transport
Biological Processintracellular iron ion homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Copper chaperone ATX1
  • Alternative names
    • Antioxidant protein 1
    • Metal homeostasis protein ATX1

Gene names

    • Name
      ATX1
    • ORF names
      N0840
    • Ordered locus names
      YNL259C

Organism names

Accessions

  • Primary accession
    P38636
  • Secondary accessions
    • D6W0T4
    • E9P8W0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002125351-73Copper chaperone ATX1

Proteomic databases

PTM databases

Expression

Induction

Expression is induced by oxygen (PubMed:7731983).
Expression is also induced by the iron-sensing trans-activator AFT1 (PubMed:9083054).

Interaction

Subunit

Homodimer (PubMed:28865724).
Interacts with CCC2 via the copper anion (PubMed:16732294).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-68HMA

Sequence similarities

Belongs to the ATX1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    73
  • Mass (Da)
    8,221
  • Last updated
    1994-10-01 v1
  • Checksum
    9BDF0B542F80EA83
MAEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQLVDVYTTLPYDFILEKIKKTGKEVRSGKQL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict8in Ref. 5; AAS56693

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L35270
EMBL· GenBank· DDBJ
AAC37428.1
EMBL· GenBank· DDBJ
Genomic DNA
X96722
EMBL· GenBank· DDBJ
CAA65485.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71535
EMBL· GenBank· DDBJ
CAA96166.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558367
EMBL· GenBank· DDBJ
AAS56693.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006947
EMBL· GenBank· DDBJ
DAA10300.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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