P38623 · RCK2_YEAST

Function

function

Serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.

Miscellaneous

Present with 1790 molecules/cell in log phase SD medium.

Catalytic activity

Activity regulation

Activated by Ser-520 phosphorylation by HOG1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site169-177ATP (UniProtKB | ChEBI)
Binding site201ATP (UniProtKB | ChEBI)
Active site313Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioncalmodulin binding
Molecular Functionprotein kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processcellular response to oxidative stress
Biological Processosmosensory signaling pathway
Biological Processregulation of meiotic nuclear division

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase RCK2
  • EC number
  • Alternative names
    • CAM kinase-like protein kinase CLK1

Gene names

    • Name
      RCK2
    • Synonyms
      CLK1, CMK3
    • ORF names
      L9672.6
    • Ordered locus names
      YLR248W

Organism names

Accessions

  • Primary accession
    P38623
  • Secondary accessions
    • D6VYP6
    • Q02532
    • Q06557

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000866041-610Serine/threonine-protein kinase RCK2
Modified residue46Phosphoserine
Modified residue50Phosphoserine
Modified residue187Phosphoserine
Modified residue350Phosphothreonine
Modified residue520Phosphoserine

Post-translational modification

Autophosphorylated. Phosphorylated by HOG1 at Ser-520 after osmotic stress.

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P38623HOG1 P324855EBI-14885, EBI-8437

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-55Disordered
Compositional bias7-28Basic and acidic residues
Compositional bias29-55Polar residues
Region99-127Disordered
Domain163-478Protein kinase
Region493-506Calmodulin-binding
Region541-564Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    610
  • Mass (Da)
    68,062
  • Last updated
    2010-10-05 v3
  • Checksum
    00DDC674F6723E6A
MLKIKALFSKKKPDQADLSQESKKPFKGKTRSSGTNNKDVSQITSSPKKSFQDKNIVQYPSVVADDHHMKSLTDELVTTIDSDSSPSDNITTENVETVTSVPAIDVHESSEGQLSSDPLISDESLSEQSEIISDIQDDSTDDDNMEDEIPEKSFLEQKELIGYKLINKIGEGAFSKVFRAIPAKNSSNEFLTKNYKAVAIKVIKKADLSSINGDHRKKDKGKDSTKTSSRDQVLKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEIVRLTYFSEDLSRHVIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTRSIKPKLRKSDDPQTKADEGIFTPGVGGGGIGIVKLADFGLSKQIFSKNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCVLYTMLCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVAKLLELEPSKRYDIDQFLDDPWLNTFDCLPKEGESSQKKAGTSERRHPHKKQFQLFQRDSSLLFSPAAVAMRDAFDIGNAVKRTEEDRMGTRGGLGSLAEDEELEDSYSGAQGDEQLEQNMFQLTLDTSTILQRRKKVQENDVGPTIPISATIRE

Sequence caution

The sequence CAA50389.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias7-28Basic and acidic residues
Compositional bias29-55Polar residues
Sequence conflict109in Ref. 1; CAA50389 and 2; AAA64421
Sequence conflict188in Ref. 1; CAA50389 and 2; AAA64421
Sequence conflict233in Ref. 1; CAA50389 and 2; AAA64421
Sequence conflict328in Ref. 1; CAA50389 and 2; AAA64421
Sequence conflict456in Ref. 1; CAA50389 and 2; AAA64421

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X71065
EMBL· GenBank· DDBJ
CAA50389.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
U23464
EMBL· GenBank· DDBJ
AAA64421.1
EMBL· GenBank· DDBJ
Genomic DNA
U20865
EMBL· GenBank· DDBJ
AAB67392.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006945
EMBL· GenBank· DDBJ
DAA09562.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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