PTP2 and MSG5 are key regulatory PPases that prevent over-activation of the calcium-induced signaling cascade under the parallel control of the SLT2 and calcineurin pathways., Genetic Interactions|Strains/Constructs|Mutants/Phenotypes|Primary Literature|Function/Process
analysis of distinct docking mechanisms mediate interactions between the Msg5 phosphatase and mating or cell integrity mitogen-activated protein kinases (MAPKs) in Saccharomyces cerevisiae
Data discovered that six non-essential protein kinase (PKase) disruptions (Deltabck1 Deltamkk1 Deltaslt2/Deltampk1 Deltamck1 Deltassk2 and Deltayak1) suppressed the Cas-phenotype of the Deltaptp2 Deltamsg5 double disruptant., Genetic Interactions|Strains/Constructs|Mutants/Phenotypes|Cell Cycle Phase Involved|Primary Literature
These findings suggest that both Ptp2p and Msg5p are involved in the G1 to S transition and vacuole morphogenesis possibly through their regulation of Slt2 pathway.
Both Fus3- and Slt2- but not Kss1-mediated gene expression is induced in cells lacking Msg5., Protein Physical Properties|Protein Processing/Modification/Regulation|Strains/Constructs|Regulatory Role|Protein-protein Interactions|Mutants/Phenotypes|Substrates/Ligands/Cofactors|Primary Literature
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