P38590 · MSG5_YEAST

Function

function

Dual specificity phosphatase that dephosphorylates MAP kinase FUS3 on both a Tyr and a Ser or Thr. Has a role in adaptation to pheromone.

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.

Catalytic activity

Features

Showing features for active site.

148950100150200250300350400450
TypeIDPosition(s)Description
Active site319Phosphocysteine intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionMAP kinase tyrosine phosphatase activity
Molecular FunctionMAP kinase tyrosine/serine/threonine phosphatase activity
Molecular Functionprotein tyrosine/serine/threonine phosphatase activity
Molecular Functionprotein tyrosine/threonine phosphatase activity
Biological Processadaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
Biological Processfungal-type cell wall organization or biogenesis
Biological Processnegative regulation of cell wall integrity MAPK cascade
Biological Processnegative regulation of MAPK cascade
Biological Processpheromone response MAPK cascade
Biological Processregulation of fungal-type cell wall organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase MSG5
  • EC number

Gene names

    • Name
      MSG5
    • ORF names
      N2480, YNL2480W
    • Ordered locus names
      YNL053W

Organism names

Accessions

  • Primary accession
    P38590
  • Secondary accessions
    • D6W1C6

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis319Loss of activity.

Variants

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The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000949161-489Tyrosine-protein phosphatase MSG5
Modified residue22Phosphoserine
Modified residue98Phosphoserine
Modified residue151Phosphoserine
Modified residue178Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Induction

By pheromone.

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-18Basic and acidic residues
Region1-30Disordered
Domain233-375Tyrosine-protein phosphatase
Region375-401Disordered
Compositional bias419-444Polar residues
Region419-489Disordered
Compositional bias449-463Basic and acidic residues
Compositional bias465-482Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    489
  • Mass (Da)
    54,217
  • Last updated
    1996-10-01 v2
  • Checksum
    0D02380B62EA48DC
MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPLMEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASIYTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLKLKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNIDMVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNSPGEEGETVHMPEEDDIGNNEVSSTTKSYSSASFRSFPMVTNLSSSPNDSSVNSSEVTPRTPATLTGARTALATERGEDDEHCKSLSQPADSLEASVDNESISTAPEQMMFLP

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-18Basic and acidic residues
Sequence conflict347-348in Ref. 1; BAA04485
Compositional bias419-444Polar residues
Compositional bias449-463Basic and acidic residues
Compositional bias465-482Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D17548
EMBL· GenBank· DDBJ
BAA04485.1
EMBL· GenBank· DDBJ
Genomic DNA
U12141
EMBL· GenBank· DDBJ
AAA99659.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71329
EMBL· GenBank· DDBJ
CAA95922.1
EMBL· GenBank· DDBJ
Genomic DNA
X02561
EMBL· GenBank· DDBJ
CAA26402.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006947
EMBL· GenBank· DDBJ
DAA10492.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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